Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4614	SMN-C3 CAS No.1449597-34-5	SMN-C3/CAS No.1449597-34-5 is an orally active SMN2 splicing modulator and has the potential to treat spinal muscular atrophy (SMA).	price>
R-R-4615	Tofersen CAS No.2088232-70-4	Tofersen (BIIB067)/CAS No.2088232-70-4 is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS).	price>
R-R-4616	PTC299 CAS No.1256565-36-2	PTC299/CAS No.1256565-36-2 is an orally active inhibitor of VEGFA mRNA translation that selectively inhibits VEGF protein synthesis at the post-transcriptional level. PTC299 is also a potent inhibitor of dihydroorotate dehydrogenase (DHODH). PTC299 shows good oral bioavailability and lack of off-target kinase inhibition and myelosuppression. PTC299 can be useful for the research of hematologic malignancies.	price>
R-R-4617	RG7800 CAS No.1449598-06-4	RG7800/CAS No.1449598-06-4 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.	price>
R-R-4618	DHX9-IN-2 CAS No.2973395-71-8	DHX9-IN-2 (example 31)/CAS No.2973395-71-8 is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 0.0698 nM that has antitumor activity.	price>
R-R-4619	JH-RE-06 CAS No.1361227-90-8	JH-RE-06/CAS No.1361227-90-8, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.	price>
R-R-4620	Zoliflodacin CAS No.1620458-09-4	Zoliflodacin (ETX0914;AZD0914)/CAS No.1620458-09-4 is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.	price>
R-R-4621	116-9e CAS No.831217-43-7	116-9e (MAL2-11B)/CAS No.831217-43-7 is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis.	price>
R-R-4622	DDD85646 CAS No.1215010-55-1	DDD85646 (IMP-366)/CAS No.1215010-55-1 is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis.	price>
R-R-4623	Fialuridine CAS No.69123-98-4	Fialuridine/CAS No.69123-98-4 is a nucleoside analog with antiviral activity. Fialuridine shows anti-orthopoxvirus activity.	price>

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