Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4617	RG7800 CAS No.1449598-06-4	RG7800/CAS No.1449598-06-4 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.	price>
R-R-4618	DHX9-IN-2 CAS No.2973395-71-8	DHX9-IN-2 (example 31)/CAS No.2973395-71-8 is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 0.0698 nM that has antitumor activity.	price>
R-R-4619	JH-RE-06 CAS No.1361227-90-8	JH-RE-06/CAS No.1361227-90-8, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.	price>
R-R-4620	Zoliflodacin CAS No.1620458-09-4	Zoliflodacin (ETX0914;AZD0914)/CAS No.1620458-09-4 is a novel spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus with the MIC90 of 0.25 μg/mL.	price>
R-R-4621	116-9e CAS No.831217-43-7	116-9e (MAL2-11B)/CAS No.831217-43-7 is a Hsp70 co-chaperone DNAJA1 inhibitor. 116-9e inhibits Simian Virus 40 (SV40) replication and DNA synthesis.	price>
R-R-4622	DDD85646 CAS No.1215010-55-1	DDD85646 (IMP-366)/CAS No.1215010-55-1 is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM). The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis.	price>
R-R-4623	Fialuridine CAS No.69123-98-4	Fialuridine/CAS No.69123-98-4 is a nucleoside analog with antiviral activity. Fialuridine shows anti-orthopoxvirus activity.	price>
R-R-4624	L82 CAS No.329227-30-7	L82/CAS No.329227-30-7 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells	price>
R-R-4625	COH29 CAS No.1190932-38-7	COH29 (RNR Inhibitor COH29)/CAS No.1190932-38-7 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.	price>
R-R-4626	L189 CAS No.64232-83-3	L189/CAS No.64232-83-3 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer.	price>

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