Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4624	L82 CAS No.329227-30-7	L82/CAS No.329227-30-7 is a selective and uncompetitive DNA ligase 1 (DNA Lig1) inhibitor (hLig1 IC50=12 μM). L82 shows anti-proliferative activity to breast cancer cells	price>
R-R-4625	COH29 CAS No.1190932-38-7	COH29 (RNR Inhibitor COH29)/CAS No.1190932-38-7 is a potent ribonucleotide reductase (RNR) inhibitor with anticancer activity. COH29 inhibits α and β subunit of RNR with IC50s of 16 μM.	price>
R-R-4626	L189 CAS No.64232-83-3	L189/CAS No.64232-83-3 is a DNA ligase inhibitor. L189 has inhibition effect for DNA Ligase I, III and IV with IC50 values of 5 μM, 9 μM and 5 μM, respectively. L189 has no cytotoxicity and individually increase cell death. L189 can be used for the research of cancer.	price>
R-R-4627	APE1-IN-1 CAS No.524708-03-0	APE1-IN-1/CAS No.524708-03-0 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC50 value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells.	price>
R-R-4628	Galidesivir hydrochloride CAS No.222631-44-9	Galidesivir (BCX4430) hydrochloride/CAS No.222631-44-9, an adenosine analog and a direct-acting antiviral agent, disrupts viral RNA-dependent RNA polymerase (RdRp) activity. Galidesivir hydrochloride is active in vitro against many RNA viral pathogens, including the filoviruses and emerging infectious agents such as MERS-CoV, SARS-CoV, and SARS-CoV-2. Galidesivir hydrochloride inhibits some negative-sense RNA viruses with EC50s ranging from ~3 to ~68 μM.	price>
R-R-4629	Bractoppin CAS No.2290527-07-8	Bractoppin/CAS No.2290527-07-8 is a potent and selective agent-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem(t) BRCT domain (binding IC50: 74 nM). Bractoppin diminishes BRCA1 recruitment to DNA breaks, in turn suppressing damage-induced G2 arrest and assembly of the recombinase, RAD51. Bractoppin preferentially inhibits BRCA1 tBRCT-dependent steps in the DNA damage response.	price>
R-R-4630	Lapachol CAS No.84-79-7	Lapachol/CAS No.84-79-7, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity.	price>
R-R-4631	DHX9-IN-1 CAS No.2973747-89-4	DHX9-IN-1 (example 160)/CAS No.2973747-89-4 is an inhibitor of ATP-dependent RNA helicase A (DHX9), with the IC50 of 9.45 nM that has antitumor activity.	price>
R-R-4632	Dasabuvir CAS No.1132935-63-7	Dasabuvir (ABT-333)/CAS No.1132935-63-7 is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively.	price>
R-R-4633	Pyrazofurin CAS No.30868-30-5	Pyrazofurin/CAS No.30868-30-5, a pyrimidine nucleoside analogue with antineoplastic activity, inhibits cell proliferation and DNA synthesis in cells by inhibiting uridine 5-phosphate (UMP) synthase. Pyrazofurin is an active, sensitive orotate-phosphoribosyltransferase inhibitor with IC50s between 0.06-0.37 µM in the three squamous cell carcinoma (SCC) cell lines Hep-2, HNSCC-14B and HNSCC-14C.	price>

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