Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4573	Dibenz[a,h]anthracene CAS No.53-70-3	Dibenz[a,h]anthracene (DBA)/CAS No.53-70-3 is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms.	price>
R-R-4574	KY386 CAS No.2787598-01-8	KY386/CAS No.2787598-01-8 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability.	price>
R-R-4575	Methotrexate CAS No.59-05-2	Methotrexate (Amethopterin)/CAS No.59-05-2, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).	price>
R-R-4576	Streptozotocin CAS No.18883-66-4	Streptozotocin (Streptozocin)/CAS No.18883-66-4 is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells.	price>
R-R-4577	ART558 CAS No.2603528-97-6	ART558/CAS No.2603528-97-6 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.	price>
R-R-4578	Propidium Iodide CAS No.25535-16-4	Propidium Iodide (PI)/CAS No.25535-16-4 is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.	price>
R-R-4579	Gemcitabine hydrochloride CAS No.122111-03-9	Gemcitabine Hydrochloride (LY 188011 Hydrochloride)/CAS No.122111-03-9 is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.	price>
R-R-4580	Remdesivir CAS No.1809249-37-3	Remdesivir (GS-5734)/CAS No.1809249-37-3, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells and 30 nM for murine hepatitis virus in brain tumor cells delayed. Remdesivir is highly effective in controlling SARS-CoV-2 (COVID-19) infection in vitro.	price>
R-R-4581	Brequinar CAS No.96187-53-0	Brequinar (DUP785)/CAS No.96187-53-0 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.	price>
R-R-4582	a-Amanitin CAS No.23109-05-9	α-Amanitin/CAS No.23109-05-9 is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.	price>

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