Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4576	Streptozotocin CAS No.18883-66-4	Streptozotocin (Streptozocin)/CAS No.18883-66-4 is an antibiotic widely used in experimental animal models of induced diabetes. Streptozotocin enters B cells via the glucose transporter (GLUT2) and causes the alkylation of DNA ( DNA-methylating ). Streptozotocin can induce the apoptosis of β cells.	price>
R-R-4577	ART558 CAS No.2603528-97-6	ART558/CAS No.2603528-97-6 is a nanomolar potent, selective, low molecular weight, allosteric DNA polymerase activity of Polθ inhibitor (IC50=7.9 nM). ART558 can be used for the research of cancer.	price>
R-R-4578	Propidium Iodide CAS No.25535-16-4	Propidium Iodide (PI)/CAS No.25535-16-4 is a nuclear staining agent that stains DNA. Propidium Iodide is an analogue of ethidine bromide that emits red fluorescence upon embedding in double-stranded DNA. Propidium Iodide cannot pass through living cell membranes, but it can pass through damaged cell membranes to stain the nucleus. Propidium Iodide has a fluorescence wavelength of 493/617 nm and a wavelength of 536/635 nm after Mosaic with DNA. Propidium Iodide is commonly used in the detection of apoptosis (apoptosis) or necrosis (necrosis), and is often used in flow cytometry analysis.	price>
R-R-4579	Gemcitabine hydrochloride CAS No.122111-03-9	Gemcitabine Hydrochloride (LY 188011 Hydrochloride)/CAS No.122111-03-9 is a pyrimidine nucleoside analog antimetabolite and an antineoplastic agent. Gemcitabine Hydrochloride inhibits DNA synthesis and repair, resulting in autophagyand apoptosis.	price>
R-R-4580	Remdesivir CAS No.1809249-37-3	Remdesivir (GS-5734)/CAS No.1809249-37-3, a nucleoside analogue with effective antiviral activity, has EC50s of 74 nM for SARS-CoV and MERS-CoV in HAE cells and 30 nM for murine hepatitis virus in brain tumor cells delayed. Remdesivir is highly effective in controlling SARS-CoV-2 (COVID-19) infection in vitro.	price>
R-R-4581	Brequinar CAS No.96187-53-0	Brequinar (DUP785)/CAS No.96187-53-0 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.	price>
R-R-4582	a-Amanitin CAS No.23109-05-9	α-Amanitin/CAS No.23109-05-9 is the principal toxin of several deadly poisonous mushrooms, exerting its toxic function by inhibiting RNA-polymerase II.	price>
R-R-4583	Branaplam CAS No.1562338-42-4	Branaplam (LMI070; NVS-SM1)/CAS No.1562338-42-4 is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.	price>
R-R-4584	Plicamycin CAS No.18378-89-7	Plicamycin (Mithramycin A)/CAS No.18378-89-7 is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression.	price>
R-R-4585	GS-441524 CAS No.1191237-69-0	GS-441524/CAS No.1191237-69-0, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM.	price>

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