Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4583	Branaplam CAS No.1562338-42-4	Branaplam (LMI070; NVS-SM1)/CAS No.1562338-42-4 is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model.	price>
R-R-4584	Plicamycin CAS No.18378-89-7	Plicamycin (Mithramycin A)/CAS No.18378-89-7 is a selective specificity protein 1 (Sp1) inhibitor. Plicamycin inhibits the growth of various cancers by decreasing Sp1 protein. Plicamycin inhibits GSTM2 promoter activity and protein expression.	price>
R-R-4585	GS-441524 CAS No.1191237-69-0	GS-441524/CAS No.1191237-69-0, predominant metabolite of Remdesivir and superior to Remdesivir against Covid-19 , shows comparable efficacy in cell-based models of primary human lung and cat cells infected with coronavirus. GS-441524 could strongly inhibits feline infectious peritonitis virus (FIPV), with an EC50 of 0.78 μM.	price>
R-R-4586	Novobiocin sodium CAS No.1476-53-5	Novobiocin (Albamycin) sodium/CAS No.1476-53-5 is a potent and orally active antibiotic. Novobiocin sodium also is a DNA gyrase inhibitor and a heat shock protein 90 (Hsp90) antagonist. Novobiocin sodium has the potential for the research of highly beta-lactam-resistant pneumococcal infections. Novobiocin sodium shows anti-orthopoxvirus activity.	price>
R-R-4587	IMT1 CAS No.2304621-31-4	IMT1/CAS No.2304621-31-4 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases.	price>
R-R-4588	Idarubicin hydrochloride CAS No.57852-57-0	Idarubicin hydrochloride/CAS No.57852-57-0 is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts.	price>
R-R-4589	Risdiplam CAS No.1825352-65-5	Risdiplam (RG7916)/CAS No.1825352-65-5 is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.	price>
R-R-4590	ML216 CAS No.1430213-30-1	ML216 (CID-49852229)/CAS No.1430213-30-1 is a potent, selective and cell permeable inhibitor of the DNA unwinding activity of BLM helicase with IC50s of 2.98 μM and 0.97 μM for BLMfull-length and BLM636-1298, respectively. ML216 inhibits ssDNA-dependent ATPase activity of BLM with a Ki of 1.76 µM. Antitumor avtivity.	price>
R-R-4591	ML-60218 CAS No.577784-91-9	ML-60218/CAS No.577784-91-9 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 μM for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs.	price>
R-R-4592	Simeprevir CAS No.923604-59-5	Simeprevir (TMC435; TMC435350)/CAS No.923604-59-5 is an oral, potent and highly specific hepatitis C virus (HCV) NS3/4A protease inhibitor with a Ki of 0.36 nM. Simeprevir inhibits HCV replication with an EC50 of 7.8 nM. Simeprevir also potently suppresses SARS-CoV-2 replication and synergizes with Remdesivir. Simeprevir inhibits the main protease (Mpro) and the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2, and also modulates host immune responses.	price>

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