Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4566	Nedisertib CAS No.1637542-33-6	Nedisertib (M3814)/CAS No.1637542-33-6 is a potent orally available selective DNA-PK inhibitor, with an IC50 of <3 nM. Anti-tumor activity.	price>
R-R-4567	VX-984 CAS No.1476074-39-1	VX-984/CAS No.1476074-39-1 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium.	price>
R-R-4568	CC-115 CAS No.1228013-15-7	CC-115/CAS No.1228013-15-7 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.	price>
R-R-4569	BAY-8400 CAS No.2763602-59-9	BAY-8400/CAS No.2763602-59-9 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer.	price>
R-R-4570	CC-115 hydrochloride CAS No.1300118-55-1	CC-115 hydrochloride/CAS No.1300118-55-1 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.	price>
R-R-4571	(R)-VX-984 CAS No.2448475-19-0	(R)-VX-984/(R)-M9831/CAS No.2448475-19-0 is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.	price>
R-R-4572	VVD-214 CAS No.3026500-20-6	VVD-214/RO7589831/VVD-133214/CAS No.3026500-20-6 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.	price>
R-R-4573	Dibenz[a,h]anthracene CAS No.53-70-3	Dibenz[a,h]anthracene (DBA)/CAS No.53-70-3 is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms.	price>
R-R-4574	KY386 CAS No.2787598-01-8	KY386/CAS No.2787598-01-8 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability.	price>
R-R-4575	Methotrexate CAS No.59-05-2	Methotrexate (Amethopterin)/CAS No.59-05-2, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).	price>

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