Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4565	3,6-Dichlorotrimellitic acid CAS No.137071-78-4	3,6-Dichlorotrimellitic acid/CAS No.137071-78-4 is the key precursor that is used for preparing a variety of dichlorinated fluoresceins and rhodamines such as TET and HEX.	price>
R-R-4566	Nedisertib CAS No.1637542-33-6	Nedisertib (M3814)/CAS No.1637542-33-6 is a potent orally available selective DNA-PK inhibitor, with an IC50 of <3 nM. Anti-tumor activity.	price>
R-R-4567	VX-984 CAS No.1476074-39-1	VX-984/CAS No.1476074-39-1 is an orally active, potent, selective and BBB-penetrated DNA-PK inhibitor. VX-984 efficiently inhibits NHEJ (non-homologous end joining) and increases DSBs (DNA double-strand breaks). VX-984 can be used for glioblastomas (GBM) and non-small cell lung cancer (NSCLC) research. VX-984 is a de novo deuterium.	price>
R-R-4568	CC-115 CAS No.1228013-15-7	CC-115/CAS No.1228013-15-7 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.	price>
R-R-4569	BAY-8400 CAS No.2763602-59-9	BAY-8400/CAS No.2763602-59-9 is an orally active, potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (IC50=81 nM). BAY-8400 can be used for the research of cancer.	price>
R-R-4570	CC-115 hydrochloride CAS No.1300118-55-1	CC-115 hydrochloride/CAS No.1300118-55-1 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling.	price>
R-R-4571	(R)-VX-984 CAS No.2448475-19-0	(R)-VX-984/(R)-M9831/CAS No.2448475-19-0 is the (R)-enantiomer of VX-984. VX-984 is a potent DNA-PK inhibitor.	price>
R-R-4572	VVD-214 CAS No.3026500-20-6	VVD-214/RO7589831/VVD-133214/CAS No.3026500-20-6 is a synthetic lethal allosteric inhibitor of WRN helicase. VVD-214 covalently binds to cysteine 727 of WRN and inhibits ATP hydrolysis and helicase activity. VVD-214 is potent in causing double-stranded DNA breaks, nuclear swelling, and cell death in high microsatellite instability (MSI) cancers.	price>
R-R-4573	Dibenz[a,h]anthracene CAS No.53-70-3	Dibenz[a,h]anthracene (DBA)/CAS No.53-70-3 is a polycyclic aromatic hydrocarbon (PAH) of considerable tumorigenicity. Dibenz[a,h]anthracene results in DNA adduct formation leading to the activation of a DNA damage response. Dibenz[a,h]anthracene induces cell cycle arrest and apoptosis via both Tp53-dependent and Tp53-independent mechanisms.	price>
R-R-4574	KY386 CAS No.2787598-01-8	KY386/CAS No.2787598-01-8 is a potent, selective inhibitor of DHX33 helicase, with the IC50 of 19 nM. KY386 inhibits U251-MG cells (DHX33-overexpressing cancer cell strain) with IC50 of 20 nM.and shows potent anti-cancer activity and moderate metabolic stability.	price>

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