Product apis-autophagy

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Catalog	name	Description	price
R-C-1410	CZC-25146 CAS:1191911-26-8	CZC-25146 is a second generation inhibitor of LRRK2 with excellent potency and selectivity.In a time-resolved fluorescence resonance energy transfer assay, CZC-25146 shows potent inhibition of both recombinant human wild type LRRK2 and G2019S mutant LRRK2 with IC50 values of 4.76nM and 6.87nM,respectively.CZC-25146 is selective against LRRK2.When treated with 184 different protein kinases and one lipid kinase,CZC-25146 inhibits only five of them with high potency including PLK4,GAK,TNK1,CAMKK2 and PIP4K2C.	price>
R-C-1507	gne7915 CAS：1351761-44-8	GNE-7915 is a potent LRRK2 kinase inhibitor,which possess an ideal balance of LRRK2 cellular potency,broad kinase selectivity,metabolic stability,and brain penetration across multiple species.GNE-7915 was reported as a potent(IC50=9nM) selective(1/187 kinases),brain-penetrant and non-toxic inhibitor of LRRK2.	price>
R-C-1522	SMER28 CAS：307538-42-7	SMER28 is a small-molecule enhancer(SMER)of autophagy,inducing autophagy independently of rapamycin in mammalian cells.	price>
R-C-1636	CVT 313 CAS:199986-75-9	CVT-313 is a potent CDK2 inhibitor with an IC50 of 0.5 microM in vitro.It has no effect on other,nonrelated ATP-dependent serine/threonine kinases.	price>
R-C-765	GSK2578215A CAS:1285515-21-0	GSK2578215A is a potent leucine-rich repeat kinase 2(LRRK2)inhibitor(IC50 values are 8.9 and 10.1 nM respectively for LRRK2[G2019S] mutant and wild-type LRRK2 respectively).	price>
R-C-768	PF-06447475 CAS:1527473-33-1	PF-06447475 is a highly potent,selective,brain penetrant LRRK2 inhibitor with IC50 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.	price>
R-C-1860	Autophinib CAS:1644443-47-9	Autophinib is a potent autophagy inhibitor with a novel chemotype with IC50 values of 90 and 40nM for autophagy in starvation induced autophagy assay and rapamycin induced autophagy assay.The IC50 value for Vps34 is 19nM in vitro.	price>
R-C-1979	IITZ-01 CAS：1807988-47-1	IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity,with an IC50 of 2.62μM for PI3Kγ.	price>
R-C-2010	DC661 CAS：1872387-43-3	DC661 is a potent palmitoyl-protein thioesterase 1(PPT1)inhibitor.DC661 inhibits autophagy.DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine(HCQ).	price>
R-C-2130	Thiamet G CAS：1009816-48-1	Thiamet G is a potent and selective inhibitor of O-GlcNAcase(OGA),which acts to remove O-GlcNAc from modified proteins,with Ki of 20 nM for human OGA.	price>

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