Product apis-autophagy

Home > products > apis> autophagy

Catalog	name	Description	price
R-R-2251	EIPA hydrochloride CAS No.1345839-28-2	EIPA hydrochloride (L593754 hydrochloride)/CAS No.1345839-28-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA hydrochloride also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-R-2252	PD146176 CAS No.4079-26-9	PD146176 (NSC168807)/CAS No.4079-26-9, a 15-Lipoxygenase (15-LO) inhibitor, inhibits rabbit reticulocyte 15-LO (Ki=197 nM, IC50=0.54 μM). PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.	price>
R-R-2253	Evogliptin tartrate CAS No.1222102-51-3	Evogliptin (DA-1229) tartrate/CAS No.1222102-51-3 is an orally active DPP4 inhibitor with significant and sustained hypoglycaemic effects in mouse models. Evogliptin tartrate also inhibits the production of inflammatory and fibrotic signals in hepatocytes by inducing autophagy. Evogliptin tartrate can be used in studies of type 2 diabetes, osteoporosis, renal impairment and chronic liver inflammation.	price>
R-R-2254	Taurine-13C2,15N CAS No.2483830-42-6	Taurine-13C2,15N/CAS No.2483830-42-6 is the 13C- and 15N- labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-R-2255	Bromhexine-d3 hydrochloride	Bromhexine-d3 (hydrochloride) is deuterium labeled Bromhexine (hydrochloride). Bromhexine hydrochloride is a potent and specific TMPRSS2 protease inhibitor with an IC50 of 0.75 μM. Bromhexine hydrochloride can prevent and manage SARS-CoV-2 infection. Bromhexine hydrochloride is an autophagy agonist. Bromhexine hydrochloride is a mucolytic cough suppressant and has the potential for a range of respiratory conditions.	price>
R-R-2256	Imipramine hydrochloride CAS No.113-52-0	Imipramine hydrochloride/CAS No.113-52-0 is an orally active tertiary amine tricyclic antidepressant. Imipramine hydrochloride is a Fascin1 inhibitor with antitumor activities. Imipramine hydrochloride also inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride stimulates U-87MG glioma cells autophagy and induces HL-60 cell apoptosis. Imipramine hydrochloride shows neuroprotective and immunomodulatory effects.	price>
R-R-2257	EIPA CAS No.1154-25-2	EIPA (L593754)/CAS No.1154-25-2 is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+ exchangers (NHE) and macropinocytosis.	price>
R-R-2258	Dasatinib monohydrate CAS No.863127-77-9	Dasatinib (BMS-354825) monohydrate/CAS No.863127-77-9 is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.	price>
R-R-2259	SB 202190 hydrochloride CAS No.350228-36-3	SB 202190 hydrochloride/CAS No.350228-36-3 is a selective p38 MAP kinase inhibitor with IC50s of 50 nM and 100 nM for p38α and p38β2, respectively. SB 202190 hydrochloride binds to the ATP pocket of the active recombinant human p38 kinase with a Kd of 38 nM. SB 202190 hydrochloride has anti-cancer activity. SB202190 hydrochloride induces autophagy.	price>
R-R-2260	LYN-1604 dihydrochloride CAS No.2310109-38-5	LYN-1604 dihydrochloride/CAS No.2310109-38-5 is a potent UNC-51-like kinase 1 (ULK1) activator (EC50=18.94 nM) for the research of triple negative breast cancer (TNBC).	price>

...