Product apis-autophagy

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Catalog	name	Description	price
R-R-2261	Pemetrexed CAS No.137281-23-3	Pemetrexed (LY231514)/CAS No.137281-23-3 is an antifolate, the Ki values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively.	price>
R-C-764	CZC54252 CAS:1191911-27-9	CZC54252 is a highly effective inhibitor of LRRK2.Its IC50 values for wild-type LRRK2 and mutant G2019S LRRK2 are 1.28 and 1.85 nm,respectively.	price>
R-C-1078	GSK2578125A CAS:1285515-21-0	GSK2578215A is a potent and highly selective LRRK2 inhibitor,which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant.	price>
R-C-1121	SKF-86002 CAS:72873-74-6	SKF-86002 is an orally active p38 MAPK inhibitor,with anti-inflammatory,anti-arthritic and analgesic activities.SKF-86002 inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid.	price>
R-C-1124	PF06447475 CAS:1527473-33-1	PF06447475 is a highly potent,selective,brain penetrant,and in vivo active LRRK2 kinase inhibitor.Leucine rich repeat kinase 2(LRRK2)has been genetically linked to Parkinson disease(PD)by genome-wide association studies(GWAS).The most common LRRK2 mutation,G2019S,which is relatively rare in the total population,gives rise to increased kinase activity.As such,LRRK2 kinase inhibitors are potentially useful in the treatment of PD.	price>
R-C-1190	LRRK2-IN-1 CAS:1234480-84-2	LRRK2-IN-1 is a potent and selective LRRK2 inhibitor with IC50 of 6 nM and 13 nM for LRRK2(G2019S)and LRRK2(WT),respectively.	price>
R-C-1237	Spautin-1 CAS:1262888-28-7	Spautin-1 is a novel autophagy inhibitor,IM inhibited the growth of K562 cells with IC50 of 1.03μM.In contrast,co-treatment with Spautin-1 increased IM-induced inhibition of cell viability with IC50 of 0.45 μM.	price>
R-C-1286	SR9009 CAS：1379686-30-2	SR9009 is a rev-ErbA agonist.It increases the constitutive repression of genes regulated by Rev-ErbA with a half-maximum inhibitory concentration(IC50)=670 nM for Rev-ErbAαand IC50=800 nM for Rev-ErbAβ.	price>
R-C-1298	SBI0206965 CAS:1884220-36-3	SBI0206965 is a potent and selective autophagy Kinase ULK1 Inhibitor.Many tumors become addicted to autophagy for survival,suggesting inhibition of autophagy as a potential broadly applicable cancer therapy.SBI-0206965 is a highly selective ULK1 kinase inhibitor in vitro and suppressed ULK1-mediated phosphorylation events in cells,regulating autophagy and cell survival.	price>
R-C-1332	JH-II127 CAS:1700693-08-8	JH-II-127 is a highly potent,selective,and brain penetrant LRRK2 inhibitor,with IC50 of 6.6 nM,2.2 nM,47.7 nM for LRRK2-wild-type,LRRK2-G2019S,LRRK2-A2016T.	price>

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