Product apis-autophagy

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Catalog	name	Description	price
R-R-2241	PHY34 CAS No.2130033-55-3	PHY34/CAS No.2130033-55-3 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer.	price>
R-R-2242	Dorsomorphin CAS No.866405-64-3	Dorsomorphin (Compound C)/CAS No.866405-64-3 is a selective and ATP-competitive AMPK inhibitor (Ki=109 nM in the absence of AMP). Dorsomorphin (BML-275) selectively inhibits BMP type I receptors ALK2, ALK3, and ALK6. Dorsomorphin can reverse autophagy activation and anti-inflammatory effect of Urolithin A (HY-100599).	price>
R-R-2243	SAR405 CAS No.1523406-39-4	SAR405/CAS No.1523406-39-4 is a first-in-class, selective, and ATP-competitive PI3K class III (PIK3C3) isoform Vps34 inhibitor (IC50=1.2 nM; Kd=1.5 nM). SAR405 inhibits autophagy induced either by starvation or by mTOR inhibition. Anticancer activity.	price>
R-R-2244	Wortmannin CAS No.19545-26-7	Wortmannin (SL-2052; KY-12420)/CAS No.19545-26-7 is a potent, selective, and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50 of 5.8 and 48 nM, respectively.	price>
R-R-2245	Felodipine-d3 CAS No.1219795-30-8	Felodipine-d3/CAS No.1219795-30-8 is the deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>
R-R-2246	Ethyl pyruvate CAS No.617-35-6	Ethyl pyruvate/CAS No.617-35-6 is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity.	price>
R-R-2247	Felodipine-d5 CAS No.1242281-38-4	Felodipine-d5/CAS No.1242281-38-4 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier.	price>
R-R-2248	FDW028 CAS No.2768426-49-7	FDW028/CAS No.2768426-49-7 a potent and highly selective FUT8 inhibitor. FUT8 exhibits potent anti-tumor activity by defucosylation and impelling lysosomal degradation of B7-H3 through the chaperone-mediated autophagy (CMA) pathway. FDW028 can be used for metastatic colorectal cancer (mCRC) research.	price>
R-R-2249	Brefeldin A CAS No.20350-15-6	Brefeldin A (BFA)/CAS No.20350-15-6 is a lactone antibiotic and a specific inhibitor of protein trafficking. Brefeldin A blocks the transport of secreted and membrane proteins from the endoplasmic reticulum to the Golgi apparatus. Brefeldin A is also an inhibitor of autophagy and mitophagy. Brefeldin A is a CRISPR/Cas9 activator. Brefeldin A inhibits HSV-1 and has anti-cancer activity.	price>
R-R-2250	Everolimus-d4 CAS No.1338452-54-2	Everolimus-d4/CAS No.1338452-54-2 is the deuterium labeled Everolimus. Everolimus (RAD001) is a Rapamycin derivative and a potent, selective and orally active mTOR1 inhibitor. Everolimus binds to FKBP-12 to generate an immunosuppressive complex. Everolimus inhibits tumor cells proliferation and induces cell apoptosis and autophagy. Everolimus has potent immunosuppressive and anticancer activities.	price>

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