Product apis-autophagy

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Catalog	name	Description	price
R-R-2221	ALLO-1 CAS No.37468-32-9	ALLO-1/CAS No.37468-32-9, an autophagy receptor, is essential for autophagosome formation around paternal organelles and directly binds to the worm LC3 homologue LGG-1 through its LC3-interacting region (LIR) motif.	price>
R-R-2222	FeTMPyP CAS No.133314-07-5	FeTMPyP/CAS No.133314-07-5 is an orally active peroxynitrite (ONOO?) scavenger. FeTMPyP reduces nitrative stress and increases autophagy. FeTMPyP reduces PARP over-activation and neuroinflammation in chronic constriction injury (CCI)-induced rats, and ameliorates functional, behavioral and biochemical deficits.	price>
R-R-2223	Chelerythrine chloride CAS No.3895-92-9	Chelerythrine chloride/CAS No.3895-92-9 is a potent, cell-permeable inhibitor of protein kinase C, with an IC50 of 660 nM. Chelerythrine chloride inhibits the Bcl-XL-Bak BH3 peptide binding with IC50 of 1.5 μM and displaces Bax from Bcl-XL. Chelerythrine chloride induces apoptosis and autophagy.	price>
R-R-2224	Retro-2 CAS No.1201652-50-7	Retro-2/CAS No.1201652-50-7 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 µM in HeLa cells. Retro-2 induces cell autophagy.	price>
R-R-2225	Onjisaponin B CAS No.35906-36-6	Onjisaponin B/CAS No.35906-36-6 is a natural product derived from Polygala tenuifolia. Onjisaponin B enhances autophagy and accelerates the degradation of mutant α-synuclein and huntingtin in PC-12 cells, and exbibits potential therapeutic effects on Parkinson disease and Huntington disease.	price>
R-R-2226	Ambroxol CAS No.18683-91-5	Ambroxol (NA-872)/CAS No.18683-91-5, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-R-2227	Ambroxol hydrochloride CAS No.23828-92-4	Ambroxol hydrochloride (NA-872 hydrochloride)/CAS No.23828-92-4, an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-R-2228	Phellodendrine chloride CAS No.104112-82-5	Phellodendrine chloride/CAS No.104112-82-5 is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis . Phellodendrine chloride promotes autophagy by regulating the AMPK/mTOR pathway and reduce the intestinal damage of ulcerative colitis.	price>
R-R-2229	Olaparib-d8	Olaparib-d8 is the deuterium labeled Olaparib (AZD2281). Olaparib is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-R-2230	Spironolactone-d7	Spironolactone-d7 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.	price>

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