Product apis-autophagy

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Catalog	name	Description	price
R-R-2211	DC-LC3in-D5 CAS No.2868312-73-4	DC-LC3in-D5/CAS No.2868312-73-4 acts as an autophagy inhibitor by attenuating LC3B lipidation. DC-LC3in-D5 binds with LC3B. DC-LC3in-D5 disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. DC-LC3in-D5 may contribute to anti-HCV or combination researchs in cancer through inhibiting autophagy.	price>
R-R-2212	Autogramin-1 CAS No.2375541-73-2	Autogramin-1/CAS No.2375541-73-2 potently inhibits autophagy induced by either starvation (IC50=0.17 μM) or mTORC1 inhibition (Rapamycin; IC50=0.44 μM).	price>
R-R-2213	U0126 CAS No.109511-58-2	U0126/CAS No.109511-58-2 is a potent, non-ATP competitive and selective MEK1 and MEK2 inhibitor, with IC50s of 72 nM and 58 nM, respectively. U0126 is an autophagy and mitophagy inhibitor.	price>
R-R-2214	STF-62247 CAS No.315702-99-9	STF-62247/CAS No.315702-99-9 is an autophagy inducer that selectively cytotoxic to VHL-deficient renal cell carcinoma (IC50 of 0.625 μM and 16 μM in RCC4 and RCC4/VHL cells, respectively).	price>
R-R-2215	Notoginsenoside Fc CAS No.88122-52-5	Notoginsenoside Fc/CAS No.88122-52-5, a protopanaxadiol- (PPD-) type saponin isolated from the leaves of Panax notoginseng, effectively counteracts platelet aggregation. Notoginsenoside Fc can accelerate reendothelialization following vascular injury in diabetic rats by promoting autophagy.	price>
R-R-2216	AS1842856 CAS No.836620-48-5	AS1842856/CAS No.836620-48-5, a specific inhibitor of Foxo1 (IC50=30 nM), potently suppresses autophagy. AS1842856 inhibits FoxO1 activity by suppressing SIRT1 expression. AS1842856 only reduces FoxO1 activity by binding to it, without affecting its transcription and protein expression.	price>
R-R-2217	(Rac)-BL-918 CAS No.2435589-07-2	(Rac)-BL-918/CAS No.2435589-07-2 is the racemate of BL-918. BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1), inducing cytoprotective autophagy for Parkinsonism disease treatment.	price>
R-R-2218	Metformin CAS No.657-24-9	Metformin (1,1-Dimethylbiguanide)/CAS No.657-24-9 inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin can cross the blood-brain barrier and triggers autophagy.	price>
R-R-2219	3,4-Dimethoxychalcone CAS No.5416-71-7	3,4-Dimethoxychalcone/CAS No.5416-71-7 is a Caloric restriction mimetics (CRMs). 3,4-Dimethoxychalcone induces the deacetylation of cytoplasmic proteins and stimulates autophagy flux. 3,4-Dimethoxychalcone can be used for cardiac and cancer diseases research.	price>
R-R-2220	Desethyl chloroquine-d4 CAS No.1189971-72-9	Desethyl chloroquine-d4/CAS No.1189971-72-9 is the deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.	price>

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