Product apis-autophagy

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Catalog	name	Description	price
R-R-2231	TFEB activator 1 CAS No.39777-61-2	TFEB activator 1/CAS No.39777-61-2 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment.	price>
R-R-2232	Dorsomorphin dihydrochloride CAS No.1219168-18-9	Dorsomorphin dihydrochloride (BML-275 dihydrochloride; Compound C dihydrochloride)/CAS No.1219168-18-9 is an AMPK inhibitor that is potent, selective, and ATP-competitive, with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits the BMP pathway by targeting the type I receptors ALK2, ALK3 and ALK6. Dorsomorphin dihydrochloride induces autophagy.	price>
R-R-2233	Typhaneoside CAS No.104472-68-6	Typhaneoside/CAS No.104472-68-6, extracted from Typha angustifolia L., Typhaneoside can inhibit the excessive autophagy of hypoxia/reoxygenation cells and increase the phosphorylation of Akt and mTOR. Typhaneoside has certain effects on the cardiovascular system, including lowering blood lipid levels, promoting antiatherosclerosis activities, as well as improving immune and coagulation function.	price>
R-R-2234	Olaparib-d4-1 CAS No.2143107-55-3	Olaparib-d4-1/CAS No.2143107-55-3 is the deuterium labeled Olaparib. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator.	price>
R-R-2235	QX77 CAS No.1798331-92-6	QX77/CAS No.1798331-92-6 is a chaperone-mediated autophagy (CMA) activator and upregulates LAMP2A expression in vitro. QX77 induces Rab11 upregulation, rescues Rab11 down-regulation and trafficking deficiency in cystinotic cells. QX77 can impede self-renewal and promote differentiation of ES cells.	price>
R-R-2236	Chloroquine CAS No.54-05-7	Chloroquine/CAS No.54-05-7 is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM).	price>
R-R-2237	Ambroxol-d5 hydrochloride CAS No.2741380-71-0	Ambroxol-d5 (hydrochloride)/CAS No.2741380-71-0 is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research.	price>
R-R-2238	N6-Isopentenyladenosine CAS No.7724-76-7	N6-Isopentenyladenosine (Riboprine)/CAS No.7724-76-7, an RNA modification found in cytokinins, which regulate plant growth/differentiation, and a subset of tRNAs, where it improves the efficiency and accuracy of translation. N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with an interesting anti-melanoma activity.	price>
R-R-2239	Taurine-13C2 CAS No.70155-54-3	Taurine-13C2/CAS No.70155-54-3 is the 13C-labeled Taurine. Taurine, a sulphur-containing amino acid and an organic osmolyte involved in cell volume regulation, provides a substrate for the formation of bile salts, and plays a role in the modulation of intracellular free calcium concentration. Taurine has the ability to activate autophagy in adipocytes.	price>
R-R-2240	Fascaplysin CAS No.114719-57-2	Fascaplysin/CAS No.114719-57-2 is an antimicrobial and cytotoxic red pigment, that can come from the marine sponge (Fascaplysinopsis sp.). Fascaplysin has been synthesized in seven steps from indole (65% yield). Fascaplysin can induces apoptosis and autophagy in human leukemia HL-60 cells. Fascaplysin shows anti-tumor activity.	price>

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