Product fluorescent-dyes-No-ROS-Rox-derivatives

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Catalog	name	Description	price
R-XASYS-00386	Ginsenoside Rc,cas:11021-14-0	Ginsenoside Rc(C53H90O22,1079.3) is a saponin that has been found in P. ginseng and has diverse biological activities, including antioxidant, anti-inflammatory, and nootropic properties.It prevents UVB-induced increases in the levels of reactive oxygen species (ROS) in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM.	price>
R-XASYS-00387	Brevilin A,cas:16503-32-5	Brevilin A(C20H26O5,346.4) is a sesquiterpene lactone that has been found in C. minima and has anticancer activity.It is an inhibitor of STAT3 signaling (IC50 = 10.6 µM in A549R cells) that inhibits the tyrosine kinase activity of the JAK1, JAK2, JAK3, and JAK4 JH1 subunit (IC50s = 11.2, 8.4, 10.2, and 11.9 µM, respectively).It inhibits proliferation of a variety of cancer cells, including A549 lung, HepG2 liver, HeLa cervical, A875 melanoma, and CT26 mouse colon carcinoma cells in a concentration-dependent manner.	price>
R-XASYS-00388	SP 600125,cas:129-56-6	SP 6000125(C14H8N2O,220.2) is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively).It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP 6000125 reduces LPS-induced production of IL-1β, IL-8, and TNF-α in isolated human peripheral blood monocytes, as well as decreases anti-CD3- and anti-CD28-induced production of IFN-γ, TNF-α, and IL-10 induced by in Th1-polarized Jurkat cells, in a concentration-dependent manner.	price>
R-XASYS-00389	Schisandrin C,cas:61301-33-5	Schisandrin C(C22H24O6,384.4) is a lignan originally isolated from Schizandrae that has diverse biological activities.It decreases viability of U937 cells in a concentration-dependent manner and induces cell cycle arrest at the G1 phase when used at a concentration of 100 μM.Schisandrin C (5-20 μM) decreases hydrogen peroxide-induced cell death and production of reactive oxygen species (ROS) in C2C12 skeletal muscle cells.	price>
R-XASYS-00390	Ligustrazine (hydrochloride),cas:76494-51-4	Ligustrazine(C8H12N2•XHCl,136.2) is a compound that has been found in L. wallichii and has diverse biological activities, including antioxidant, anti-inflammatory, neuroprotective, and anticancer properties.It inhibits hydrogen peroxide-induced decreases in cell viability and the levels of superoxide dismutase (SOD) and glutathione peroxidase (GPX) and increases in reactive oxygen species (ROS) and malondialdehyde (MDA) levels in human umbilical vein endothelial cells (HUVECs) when used at concentrations of 100 and 150 μg/ml.	price>
R-XASYS-00391	2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine,cas:105650-23-5	2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)(C13H12N4,224.3) is a food-derived carcinogen that is found in high temperature-cooked fish and meat.In humans, PhIP is metabolized by the cytochrome (CYP) P450 isoform CYP1A2 and conjugated by N-acetyltransferase or sulfotransferase to a metabolite that reacts with DNA to form adducts, which are directly correlated with increased risk of breast, colon, and prostate cancers.	price>
R-XASYS-00392	Fenretinide-d4,cas:2118244-64-5	Fenretinide(C26H29D4NO2,395.6) is intended for use as an internal standard for the quantification of fenretinide by GC- or LC-MS. Fenretinide is a synthetic derivative of retinoic acid and an inhibitor of dihydroceramide desaturase (IC50 = 2.32 µM).It promotes the generation of reactive oxygen species (ROS), the degradation of anti-apoptotic MCL-1, and the cleavage of pro-apoptotic PKCδ.	price>
R-XASYS-00393	Kaempferol-3-glucoside,cas:480-10-4	Kaempferol-3-glucoside(C21H20O11,448.4) is an orally bioavailable flavonoid that has been isolated from the leaves of D. kaki and R. agrestis and has anti-inflammatory activity.Kaempferol-3-glucoside (20-80 µg/ml) dose-dependently inhibits IL-1β-stimulated nitric oxide and prostaglandin E2 (PGE2) production in patient-derived osteoarthritis chondrocytes, an effect that is blocked by the PPAR-γ inhibitor GW 9662.	price>
R-XASYS-00394	Decursin,cas:5928-25-6	Decursin(C19H20O5,328.4) is a phytochemical originally isolated from A. gigas with diverse biological activities.It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM.	price>
R-XASYS-00395	Umbelliferone,cas:93-35-6	Umbelliferone(C9H6O3,162.1) is a naturally occurring derivative and metabolite of coumarin that has diverse biological activities including antitumor and antidepressant-like properties.It inhibits the growth of a variety of human cell lines, including human ACHN renal, A549 lung, HCT15 colon, and LNCaP prostate carcinoma as well as Dakiki myeloma and HL-60 lymphoma cells, when used at concentrations ranging from 250 to 300 µg/ml.	price>

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