SP 600125,cas:129-56-6

SP 6000125(C14H8N2O,220.2) is a pan-inhibitor of JNK (IC50s = 0.04, 0.04, and 0.09 µM for JNK1, -2, and -3, respectively).It is greater than 300-fold selective for these enzymes over a panel of 17 additional kinases at 10 µM. SP 6000125 reduces LPS-induced production of IL-1β, IL-8, and TNF-α in isolated human peripheral blood monocytes, as well as decreases anti-CD3- and anti-CD28-induced production of IFN-γ, TNF-α, and IL-10 induced by in Th1-polarized Jurkat cells, in a concentration-dependent manner.

msds of SP 600125