Product apis-transmembrane-transporters

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Catalog	name	Description	price
R-C-1357	AZD3965 CAS No. 1448671-31-5	AZD3965 is a selective inhibitor of monocarboxylate transporter 1(MCT1)with a binding affinity of 1.6 nM,is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.In vivo,AZD3965 is well tolerated and induces a dose and time dependent accumulation of lactate in the tumours,suppresses tumour growth and in the Raji model potentiates the effects of Rituxan,doxorubicin and bendamustine. The selective inhibition of lactate transport by the MCT1 inhibitor AZD3965 offers an novel mechanism for targeting the metabolic phenotype in tumours that preferentially express MCT1.	price>
R-C-1358	KS176 CAS No. 1253452-78-6	KS176 is a potent and selective inhibitor of the breast cancer resistance protein(BCRP)multidrug transporter(IC50 values are 0.59 and 1.39 μM in Pheo A and Hoechst 33342 assays respectively).Displays no inhibitory activity against P-gp or MRP1.	price>
R-C-1411	ML-365 CAS:947914-18-3	ML365 is a selective two-pore domain potassium channel KCNK3/TASK1 inhibitor, with an IC50 of 4 nM.ML365 acts as a pharmacological tool that can be used to examine the specific roles of TASK1 channels.	price>
R-C-1415	KPT330 CAS:1393477-72-9	KPT-330 inhibitor of CRM1(XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.	price>
R-C-1416	Verdinexor (KPT-335) CAS: 1392136-43-4	Verdinexor（KPT-335)is an orally bioavailable Selective Inhibitor of Nuclear Export(SINE).KPT-335 inhibited proliferation,blocked colony formation,and induced apoptosis of treated cells at biologically relevant concentrations of drug.Additionally,KPT-335 downregulated XPO1 protein while inducing a concomitant increase in XPO1 messenger RNA.KPT-335 treatment of cell lines upregulated the expression of both protein and mRNA for the tumor suppressor proteins p53 and p21,and promoted their nuclear localization.	price>
R-C-1417	KPT276 CAS:1421919-75-6	KPT-276 is an orally bioavailable inhibitor of Exportin 1(XPO1/CRM1)with anticancer activity.In vivo,KPT-276 increases survival and reduces spleen weight and white blood cell count in an MV4-11 acute myeloid leukemia(AML)mouse xenograft model.	price>
R-C-1425	Cariporide CAS:159138-80-4	Cariporide is a selective and potent inhibitor of NHE1 with an IC50 of 30 nM for hNHE1 in CHO-K1 cells.	price>
R-C-1427	Deracoxib CAS:169590-41-4	Deracoxib is an NSAID and COX-2 inhibitor used to treat osteoarthritis.It induces cell cycle arrest and apoptosis in mammary tumor cells,decreases platelet aggregation,and lowers inflammatory responses.	price>
R-C-1441	OAC2 CAS：6019-39-2	OAC2 is an Oct4-activating compound which activates expression through the Oct4 gene promoter.Octamer-binding transcription factor 4(Oct4)is a transcription factor which,with Sox2,Klf4,and c-Myc,is involved in the reprogramming of somatic cells to produce pluripotent stem cells.	price>
R-C-1479	SEA0400 CAS:223104-29-8	SEA0400 is a selective and potent inhibitor of the Na+-Ca2+ exchanger(NCX)that inhibits Na+-dependent Ca2+ uptake in cultured neurons, astrocytes,and microglia with IC50 of 33 nM,5.0nM and 8.3 nM,respectively.SEA0400 prevents sodium nitroprusside(SNP)from increasing ERK and p38 MAPK phosphorylation and production of reactive oxygen species(ROS)in an extracellular Ca(2+)-dependent manner.	price>

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