Product apis-transmembrane-transporters

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Catalog	name	Description	price
R-C-1497	SKF96365 CAS:130495-35-1	SKF96365,originally identified as a blocker of receptor-mediated calcium entry, is widely used diagnostically,as a blocker of transient receptor potential canonical type(TRPC)channels.	price>
R-C-1589	SB 366791 CAS:472981-92-3	SB-366791 is a potent,competitive and selective vanilloid receptor(VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nM target:VR1/TRPV1 IC 50:5.7±1.2 nM[1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08.	price>
R-C-1666	NQ301 CAS：130089-98-4	NQ301(Compound 211),an antiplatelet and antithrombotic agent,is a selective CD45 inhibitor with IC50 of 200 nM.NQ301 inhibits thromboxane A2 receptor(TXA2)and synthase activity in rabbit platelets.	price>
R-C-1700	Lesinurad CAS： 878672-00-5	Lesinurad is a URAT1 and OAT inhibitor,is determined to be a substrate for the kidney transporters OAT1 and OAT3 with Km values of 0.85 and 2µM, respectively.	price>
R-C-1747	Verinurad (RDEA3170) CAS：1352792-74-5	Verinurad(RDEA3170)is a high-affinity inhibitor of the URAT1 transporter with an IC50 of 25 nM for inhibiting transport activity of human URAT1.It inhibits the related URAT1 homologs OAT4 and OAT1 with approximately 200-fold lower affinity compared to URAT1 with IC50 values of 5.9µM and 4.6µM,respectively.	price>
R-C-1801	BTB06584 CAS：219793-45-0	BTB06584 is a selective and IF1-dependent mitochondrial F1Fo-ATPase inhibitor without compromising ATP synthesis.BTB06584 can delays ischaemic cell death.	price>
R-C-1811	GSK2981278 CAS:1474110-21-8	GSK2981278 is a potent and selective RORγ inverse agonist.GSK2981278 inhibits activation of the il17 promoter and interferes RORγ-DNA binding.	price>
R-C-1960	GLPG1837 CAS：1654725-02-6	GLPG-1837（ABBV-974)is a novel cystic fibrosis transmembrane conductance regulator(CFTR)potentiator1.GLPG1837 was generally safe and well tolerated in healthy subjects up to the highest dose of 800 mg twice daily for 2 weeks. GLPG1837 shows enhanced efficacy on CFTR mutants harboring Class III mutations compared to Ivacaftor,the first marketed potentiator.	price>
R-C-2000	SR1078 CAS:1246525-60-9	SR1078 is an agonist of retinoic acid receptor-related orphan receptors(ROR) RORα/γ;increases transcription of RORα target genes;thought to increase p53 stability.	price>
R-C-2009	LIT-927 CAS:2172879-52-4	LIT-927 is a Locally and Orally Active CXCL12 Neutraligand with Anti-inflammatory Effect in a Murine Model of Allergic Airway Hypereosinophilia. displays a higher solubility.LIT-927 reduces eosinophil recruitment in a murine model of allergic airway hypereosinophilia.	price>

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