Product apis-transmembrane-transporters

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Catalog	name	Description	price
R-C-2011	BAY-8002 CAS：724440-27-1	BAY-8002 is a novel MCT1 inhibitor and potently suppress bidirectional lactate transport.BAY-8002 significantly increases intratumor lactate levels and transiently modulates pyruvate levels.	price>
R-C-2012	V-9302 CAS：1855871-76-9	V-9302 is a competitive antagonist of transmembrane glutamine flux.V-9302 selectively and potently targets the amino acid transporter ASCT2(SLC1A5)not ASCT1.V-9302 inhibits ASCT2-mediated glutamine uptake(IC50=9.6 µM)in HEK-293 cells.	price>
R-C-2033	CDN1163 CAS： 892711-75-0	CDN1163 is a SERCA2 allosteric activator.It increases Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice.Rescues HEK cells from ER stress-induced cell death.	price>
R-C-2087	Elexacaftor (VX-445) CAS:2216712-66-0	Elexacaftor(VX-445,Compound 1)is a modulator of cystic fibrosis transmembrane conductance regulator(CFTR).Elexacaftor(VX-445,Compound 1)facilitates the processing and trafficking of CFTR to increase the amount of CFTR at the cell surface.	price>
R-C-2296	Levetiracetam (UCB-L059) CAS:102767-28-2	Levetiracetam, an antiepileptic agent,binds the synaptic vesicle protein SV2A. Levetiracetam enhances Temozolomide effect on glioblastoma stem cell proliferation and apoptosis.Levetiracetam modulates HDAC levels ultimately silencing MGMT,thus increasing Temozolomide effectiveness.A chemosensitizer agent.	price>
R-C-2298	MCU-i4 CAS:371924-24-2	MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU)complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx.	price>
R-C-2301	Ranolazine CAS:95635-55-5	Ranolazine(CVT 303)is an anti-angina drug that achieves its effects by inhibiting the late phase of inward sodium current(INa and IKr with IC50 values of 6μM and 12μM, respectively)without affecting heart rate or blood pressure(BP).Ranolazine is also a partial fatty acid oxidation(FAO)inhibitor.Antianginal agent.	price>
R-C-2302	Isradipine CAS: 75695-93-1	Isradipine(PN 200-110)is an orally active L-type calcium channel blocker.Isradipine,as a powerful peripheral vasodilator,is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation.Isradipine is a potentially viable neuroprotective agent for Parkinson is disease.	price>
R-C-2304	Manidipine CAS:89226-50-6	Manidipine is a calcium channel blocker(dihydropyridine type)that is used clinically as an antihypertensive.Manidipine is a lipophilic,third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature,thereby inducing marked peripheral vasodilation with negligible cardiodepression.In addition,manidipine does not significantly affect norepinephrine levels,suggesting a lack of sympathetic activation.	price>
R-C-2305	Nisoldipine CAS:63675-72-9	Nisoldipine(BAY-k 5552;Sular)is a calcium channel blocker belonging to the dihydropyridines class,specific for L-type Cav1.2 with IC50 of 10nM.	price>

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