Product apis-stem-cells-wwnt

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Catalog	name	Description	price
R-C-1918	SKL 2001 CAS:909089-13-0	SKL2001 is an agonist of the Wnt/β-catenin pathway,with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.	price>
R-C-1936	GIGANTOL CAS:67884-30-4	Gigantol is a bibenzyl compound derived from several medicinal orchids.Giganto shows promising therapeutic potential against cancer cells.Gigantol is a novel inhibitor of the Wnt/β-catenin pathway.	price>
R-C-1947	IMR-1 CAS:310456-65-6	IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with an IC50 of 26μM.IMR-1 prevents the recruitment of Mastermind-like 1(Maml1)to the Notch Ternary Complex(NTC)on chromatin,inhibits Notch target gene transcription and dramatically inhibits tumor growth.	price>
R-C-2134	Ac-COA Synthase Inhibitor CAS：508186-14-9	Ac-CoA Synthase Inhibitor1 is a potent,reversible acetate-dependent acetyl-CoA synthetase 2(ACSS2)inhibitor with an IC50 of 0.6µM.Ac-CoA Synthase Inhibitor1 inhibits the respiratory syncytial virus(RSV).	price>
R-C-2508	PF-5274857 CAS:1373615-35-0	PF-5274857 is a potent,selective,orally active and brain-penetrant antagonist of Smo,with an IC50 of 5.8nM and Ki of 4.6nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.	price>
R-C-2558	BML-284 CAS:853220-52-7	BML-284 is a potent and cell-permeable Wnt signaling activator.BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700nM.	price>
R-C-2663	XAV-939 CAS:284028-89-3	XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling.XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2(IC50s of 5 and 2nM,respectively),thereby stimulating β-catenin degradation.XAV939 binds tightly to the catalytic(PARP)domains of TNKS1 and TNKS2(Kds of 99 and 93nM,respectively).	price>
R-C-3265	U18666A CAS：3039-71-2	U18666A, an intra-cellular cholesterol transport inhibitor, inhibits replication of Ebola virus, dengue virus, and human hepatitis C virus.Our products are only suitable for scientific research experiments, not for clinical experiments and human body.	price>
R-C-3266	TAK-441 CAS：1186231-83-3	TAK-441 is a pyrrolo[3,2-c]pyridine derivative,as a highly potent and orally active hedgehog signaling inhibitor.Our products are only suitable for scientific research experiments, not for clinical experiments and human body.	price>
R-C-3267	GANT61 CAS：500579-04-4	GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription,inhibits hedgehog with IC50 of 5μM,displays selectivity over other pathways,such as TNF and glucocorticoid receptor gene transactivation.Our products are only suitable for scientific research experiments, not for clinical experiments and human body.	price>

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