Product apis-stem-cells-wwnt

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Catalog	name	Description	price
R-C-3373	Semagacestat (LY450139) CAS:425386-60-3	Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid(Aβ42),Aβ38 and Aβ40 with IC50s of 10.9,12 and 12.1nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM.Semagacestat can be used for the research of alzheimer is disease.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3374	BMS 433796 CAS :935525-13-6	BMS 433796 is a γ-secretase inhibitor with Aβ lowering activity in a transgenic mouse model of Alzheime is disease.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3375	BMS 299897 CAS:290315-45-6	BMS 299897 is an orally active, potent γ-secretase inhibitor (IC50 = 12 nM). Inhibits Aβ40 and Aβ42 formation in vitro (IC50 values are 7.4 and 7.9 nM respectively) and reduces Aβ in the brain, plasma and cerebrospinal fluid in vivo.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3376	E 2012 CAS: 870843-42-8	E 2012 is a potent gamma(γ)secretase modulator without affecting Notch processing. E 2012 inhibits 3β-hydroxysterol Δ24-reductase(DHCR24)at the final step in the cholesterol biosynthesis.E 2012 aims at Alzheimer s disease by reduction of amyloid β-42, and induces cataract following repeated doses in the rat.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3377	MRK 560 CAS:677772-84-8	MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3378	L-685458 CAS:292632-98-5	L-685458 is a potent transition state analog(TSA)γ-secretase inhibitor(GSI).L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17nM,shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3nM, respectively.L-685458 can be used for the research of alzheimer is disease(AD)and cancers.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3379	Begacestat(GSI-953) CAS:769169-27-9	Begacestat is a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer is disease.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3380	TC-E 5006 CAS:1257395-14-4	TC-E 5006 is a gamma-secretase modulator. Reduces Aβ42 levels in vitro(EC50=390nM) and in vivo.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3381	IMR-1A CAS:331862-41-0	IMR-1A is the metabolite of IMR-1.IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 umol/L.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>
R-C-3382	BMS-906024 CAS:1401066-79-2	BMS-906024 is an oral and selective gamma secretase inhibito(GSI)that is a small molecule Notch inhibitor.Our products are only suitable for scientific research experiments,not for clinical experiments and human body.	price>

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