Product apis-stem-cells-wwnt

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Catalog	name	Description	price
R-C-1396	Glasdegib (PF-04449913) CAS：1095173-27-5	Glasdegib,also known as PF-04449913,is an orally bioavailable small-molecule inhibitor of the Hedgehog(Hh)signaling pathway with potential antineoplastic activity.Hedgehog inhibitor PF-04449913 appears to inhibit Hh pathway signaling. The Hh signaling pathway plays an important role in cellular growth, differentiation and repair.Constitutive activation of Hh pathway signaling has been observed in various types of malignancies.	price>
R-C-1440	OAC1 CAS：300586-90-7	OAC1 is an Oct-4 activator,octamer-binding transcription factor 4(Oct4)-activating compound,that enhances the iPSC reprogramming efficiency and accelerated the reprogramming process by 20-fold.OAC-1 also upregulates mRNA expression of Oct-4,Sox-2 and Nanog,as well as Tet1.	price>
R-C-1468	ISX9 CAS:832115-62-5	Isoxazole 9(Isx-9)is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells(NSPCs).Isoxazole 9(Isx-9)activates multiple pathways including TGF-β induced epithelial–mesenchymal transition(EMT)signaling,canonical and non-canonical Wnt signaling at different stages of cardiac differentiation.	price>
R-C-1484	Cyclopamine CAS：4449-51-8	Cyclopamine is a naturally occurring chemical that belongs to the group of steroidal jerveratrum alkaloids.It is a teratogen isolated from the corn lily (Veratrum californicum)that causes usually fatal birth defects.It can prevent the fetal brain from dividing into two lobes(holoprosencephaly)and cause the development of a single eye(cyclopia).	price>
R-C-1676	SANT-1 CAS:304909-07-7	SANT-1 is a potent,cell-permeable inhibitor of Sonic hedgehog(Shh)signaling;high affinity antagonist of smoothened activity(KD=1.2nM).Inhibits smoothened agonist effects with an IC50 of 20 nM(in Shh-LIGHT2 cells).	price>
R-C-1690	CP21R7(CP21) CAS ：125314-13-8	CP21R7 is potent GSK-3β inhibitor,with an IC50 of 1.8 nM;CP21R7 also shows inhibitory activitiy against PKCα,with an IC50 of 1900 nM.	price>
R-C-1710	MK-4101 CAS:935273-79-3	MK-4101,a potent inhibitor of the Hedgehog pathway,shows anti-tumor activity through the inhibition of proliferation and induction of extensive apoptosis in tumor cells.	price>
R-C-1750	Amcasertib (BBI503) CAS：1129403-56-0	Amcasertib(BBI503),a first-in-class cancer stemness kinase inhibitor,is claimed to inhibit Nanog and other CSC pathways by targeting kinases with potential anticancer activity.	price>
R-C-1761	LGK-974 CAS：1243244-14-5	LGK974 is a highly potent,selective and orally bioavailable Porcupine inhibitor(Wnt signaling antagonist)with an IC50<1nM in the Wnt signaling reporter assay and Porcupine binding assay.	price>
R-C-1886	Crenigacestat (LY3039478) CAS：1421438-81-4	LY3039478 is a orally bioavailable,novel small molecule Notch inhibitor with an IC50 of ~1nM in most of the tumor cell lines tested.	price>

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