Product apis-proteases

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Catalog	name	Description	price
R-C-2148	Bortezomib CAS:179324-69-7	Bortezomib(PS-341,Velcade,LDP-341,MLM341,NSC 681239)is a potent 20S proteasome inhibitor with Ki of 0.6 nM.It exhibits favorable selectivity towards tumor cells over normal cells.Bortezomib(PS-341)inhibits NF-κB and induces ERK phosphorylation to suppress cathepsin B and inhibit the catalytic process of autophagy in ovarian cancer and other solid tumors.	price>
R-C-2229	Solasodine CAS:126-17-0	Solasodine(Purapuridine,Solancarpidine,Solasodin,Salasodine,Salasdine)is a poisonous alkaloid chemical compound that occurs in plants of the Solanaceae family.Solasodine reduces the mRNA level of matrix metalloproteinase-2(MMP-2), MMP-9 and extracellular inducer of matrix metalloproteinase(EMMPRIN),but increases the expression of reversion-inducing cysteine-rich protein with kazal motifs(RECK).Solasodine downregulates oncogenic microRNA-21(miR-21),which has been known to target RECK.Solasodine also reduces PI3K/Akt signaling pathways and downregulates expression of miR-21.	price>
R-C-2312	Azelnidipine CAS:123524-52-7	Azelnidipine(CS 905;Calblock)is a novel dihydropyridine derivative,a L-type calcium channel blocker,and an antihypertensive.	price>
R-C-2504	Ixazomib citrate (MLN9708) CAS：1239908-20-3	Ixazomib citrate(MLN9708)is a reversible inhibitor of the chymotrypsin-like proteolytic β5 site of the 20S proteasome with an IC50 of 3.4nM and a Ki of 0.93nM.	price>
R-C-2505	PR171(Carfilzomib) CAS:868540-17-4	Carfilzomib(PR-171)is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.	price>
R-C-2506	LY411575 CAS:209984-57-6	LY-411575 is a potent γ-secretase inhibitor with IC50 of 0.078 nM/0.082nM (membrane/cell-based),and also inhibits Notch S3 cleavage with IC50 of 0.39nM.	price>
R-C-2511	MDL28170 CAS:88191-84-8	MDL-28170(Calpain Inhibitor III)is a potent and selective calpain inhibitor of calpain that penetrates the blood-brain barrier and inhibits brain cysteine protease activity after systemic administration.MDL-28170 is also an inhibitor of γ-secretase.	price>
R-C-2512	LCZ696(Sacubitril;Valsartan) CAS:936623-90-4	Sacubitril/Valsartan(LCZ696),comprised Valsartan and Sacubitril(AHU377)in 1:1 molar ratio,is a first-in-class,orally bioavailable,and dual-acting angiotensin receptor-neprilysin(ARN)inhibitor for hypertension and heart failure. Sacubitril/Valsartan ameliorates diabetic cardiomyopathy by inhibiting inflammation,oxidative stress and apoptosis.	price>
R-C-2572	Metolazone CAS:17560-51-9	Metolazone(SR-720-22)is primarily used to treat congestive heart failure and high blood pressure.	price>
R-C-2573	Delanzomib (CEP-18770) CAS:847499-27-8	Delanzomib(CEP-18770)is a potent and orally active chymotrypsin-like activity of the proteasome inhibitor with an IC50 of 3.8nM.Delanzomib inhibits NF-κB activity,induces cancer cell apoptotic,and has strong antiangiogenic and anti-cancer activities.	price>

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