Product apis-proteases

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Catalog	name	Description	price
R-C-1643	FYX 051(Topiroxostat) CAS:577778-58-6	Topiroxostat(FYX-051)is a potent and orally active xanthine oxidoreductase (XOR)inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity(18.6%).Topiroxostat has the potential for hyperuricemia treatment.	price>
R-C-1716	Telaglenastat (CB-839) CAS:1439399-58-2	Telaglenastat(CB-839)is a potent,selective,and orally bioavailable glutaminase inhibitor with IC50 of 24nM for recombinant human GAC.CB-839(Telaglenastat)inudces autophagy and has antitumor activity.	price>
R-C-1727	Boceprevir (SCH-503034) CAS:394730-60-0	Boceprevir(EBP 520)is a potent, highly selective,orally bioavailable HCV NS3 protease inhibitor with a Ki of 14nM in both enzyme assay and an EC90 of 350nM in cell-based replicon assay.Boceprevir inhibits SARS-CoV-2 3CLpro activity.	price>
R-C-1763	GK921 CAS：1025015-40-0	GK921 is a transglutaminase 2(TGase)inhibitor with an IC50 of 7.71μM for human recombinant TGase 2.	price>
R-C-1832	MG-132 CAS:1211877-36-9	MG132(Z-Leu-Leu-Leu-al)is a potent cell-permeable proteasome and calpain inhibitor with IC50s of 0.1μM and 1.2μM for the inhibition of proteasome and calpain,respectively.MG132 activates autophagy and induces apoptosis in tumor cells.	price>
R-C-1893	Fostemsavir(BMS-663068) CAS：864953-29-7	Fostemsavir(BMS-663068,Rukobia),the phosphonooxymethyl prodrug of BMS626529,is an attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells with EC50 of<10nM.	price>
R-C-1896	Glecaprevir CAS：1365970-03-1	Glecaprevir(ABT-493,A-1282576)is a novel HCV NS3/4A protease inhibitor,with IC50 values ranging from 3.5 to 11.3nM.	price>
R-C-1933	ALVELESTAT (AZD 9668) CAS:848141-11-7	Alvelestat(AZD9668,Avelestat)is an oral,highly selective inhibitor of neutrophil elastase(NE)with IC50 and Ki of 12nM and 9.4nM,at least 600-fold more selective over other serine proteases.	price>
R-C-1957	Calpeptin CAS:117591-20-5	Calpeptin is a potent,cell-permeable calpain inhibitor with ID50 of 52 nM, 34 nM,138nM,and 40 nM for Calpain I(porcine erythrocytes),Calpain II(porcine kidney),Papainb,and Calpain I(human platelets),respectively.Calpeptin attenuates apoptosis and intracellular inflammatory changes in muscle cells.	price>
R-C-1962	CD437 CAS：125316-60-1	CD437 is a selective Retinoic Acid Receptor γ(RARγ)agonist.	price>

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