Product apis-proteases

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Catalog	name	Description	price
R-C-971	0prozomib(ONX0912) cas:935888-69-0	Oprozomib(onx 0912;pr047)is an oral biocompatible inhibitor, which can inhibit the ct-l activity of 20S proteasome (20S proteasome)β 5/LMP7 with IC50 of 36 nm /82 nm.	price>
R-C-977	N6022 cas:1208315-24-5	N6022 is a new and first-class drug with strong inhibitory activity on S-nitrosoglutathione reductase (gsnor).Gsnor is an enzyme that plays an important role in the metabolism of S-nitrosoglutathione(GSNO)and the maintenance of nitric oxide(no)homeostasis.N6022 is a highly binding,specific and reversible gsnor inhibitor with IC50 of 8 nm and Ki of 2.5 nm.	price>
R-C-979	Trelagliptin(syr472) cas:865759-25-7	Trelagliptin(SYR-472)succinate is a potent, orally active and highly selective DPP-4 inhibitor with an IC50 of 4 nM.Trelagliptin succinate improves glycemic control in vivo and can be used for the study of type 2 diabetes mellitus (T2DM).	price>
R-C-985	Asunaprevir(BMS-650032) cas:630420-16-5	Asunaprevir(BMS-650032)is an orally bioavailable inhibitor of the hepatitis C virus enzyme serine protease NS3 that is necessary for protein processing required for viral replication.	price>
R-C-1018	ONX0914(PR-957)	ONX 0914 is an immunoproteasome inhibitor with potential treatment applications in autoimmune disorders,such as rheumatoid arthritis,inflammatory bowel disease and lupus.ONX 0914 was designed to be a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome.	price>
R-C-1110	MK0822 CAS：603139-19-1	Odanacatib is a potent,selective,and neutral inhibitor of cathepsin K(IC50s=0.2 and 1 nM for human and rabbit enzymes,respectively),a protease involved in osteoclastic bone resorption.It demonstrates high selectivity for cathepsin K over cathepsins B,L,and S.Formulations containing odanacatib reduce bone resorption,with lesser reductions in bone formation,resulting in increased bone mineral density.	price>
R-C-1159	omarigliptin CAS:1226781-44-7	Omarigliptin(MK-3102)is a competitive,reversible inhibitor of DPP-4(IC50=1.6 nM,Ki=0.8nM).It is highly selective over all proteases tested (IC50>67 μM), including QPP,FAP,PEP,DPP8,and DPP9 and has weak ion channel activity (IC50>30 μM at IKr,Caγ1.2,and Naγ1.5).	price>
R-C-1208	Epacadostat (INCB 024360) CAS:1204669-58-8	Epacadostat(INCB 024360)is a potent and selective indoleamine 2,3-dioxigenase 1 (IDO1)inhibitor with an IC50 of 71.8 nM.	price>
R-C-1210	Marimastat CAS:154039-60-8	Marimastat(BB2516)is a broad spectrum and orally bioavailable inhibitor of MMPs,with potent activity against MMP-9(IC50=3nM),MMP-1(IC50=5nM),MMP-2 (IC50=6nM),MMP-14(IC50=9nM)and MMP-7(IC50=13 nM),used in the treatment of cancer.Marimastat(BB2516)is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels.As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.	price>
R-C-1212	oltipraz CAS：64224-21-1	Oltipraz has an inhibitory effect on HIF-1αactivation in a time-dependent manner,completely abrogating HIF-1αinduction at≥10μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.Oltipraz is a potent Nrf2 activator.	price>

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