Product apis-proteases

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Catalog	name	Description	price
R-C-1210	Marimastat CAS:154039-60-8	Marimastat(BB2516)is a broad spectrum and orally bioavailable inhibitor of MMPs,with potent activity against MMP-9(IC50=3nM),MMP-1(IC50=5nM),MMP-2 (IC50=6nM),MMP-14(IC50=9nM)and MMP-7(IC50=13 nM),used in the treatment of cancer.Marimastat(BB2516)is an angiogenesis and metastasis inhibitor, which limits the growth and production of blood vessels.As an antimetatstatic agent it prevents malignant cells from breaching the basement membranes.	price>
R-C-1212	oltipraz CAS：64224-21-1	Oltipraz has an inhibitory effect on HIF-1αactivation in a time-dependent manner,completely abrogating HIF-1αinduction at≥10μM concentrations, the IC50 of Oltipraz for HIF-1α inhibition is 10 μM.Oltipraz is a potent Nrf2 activator.	price>
R-C-1255	Quisinostat CAS:875320-29-9	SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor.SB-3CT is a 2-[(arylsulfonyl)methyl]thiirane that achieves potent inhibition,by a thiirane-opening mechanism,of the MMP2 and MMP9 zinc metalloproteases.SB-3CT attenuates behavioral impairments and hippocampal loss after traumatic brain injury in rat.Matrix metalloproteinases(MMPs)are involved in a number of activities including angiogenesis and embryogenesis.In particular,gelatinases A (MMP-2)and B(MMP-9),are thought to facilitate tumor metastasis.	price>
R-C-1266	LDN-57444 CAS：668467-91-2	LDN-57444 is a Uch-L1 inhibitor(ubiquitin C-terminal hydrolase-L1)with Ki=0.4 μ M.Ubiquitin carboxy-terminal hydrolase L1(UCH-L1)is an intracellular protein abundantly expressed in neurons,and a mutation in UCH-L1 has been identified in familial Parkinson is disease.	price>
R-C-1278	LP-533401 CAS：945976-43-2	LP533401 is an inhibitor of tryptophan hydroxylase 1,which regulates serotonin production in the gut.LP533401 has an anabolic effect in bone.Inhibiting GDS biosynthesis could become a new anabolic treatment for osteoporosis.	price>
R-C-1313	Ilomastat (GM6001, Galardin) CAS:142880-36-2	Ilomastat,also known as GM6001 and galardin,is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity.GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc.Examples of enzymes that ilomastat inhibit include thermolysin,peptide deformylase,and anthrax lethal factor endopeptidase(LF) produced by the bacterium Bacillus anthracis.	price>
R-C-1402	ABT530 CAS:1353900-92-1	Pibrentasvir(ABT-530)is a novel and pan-genotypic hepatitis C virus(HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6.	price>
R-C-1585	VR23 CAS : 1624602-30-7	VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes(IC50=1nM),chymotrypsin-like proteasomes(IC50=50-100nM),and caspase-like proteasomes(IC50=3uM).	price>
R-C-1587	T-5224 CAS:530141-72-1	T-5224 is a selective inhibitor of transcription factor c-Fos/activator protein (AP)-1 with anti-inflammatory effects.T-5224 specifically inhibits the DNA binding activity of c-Fos/c-Jun and the IL-1β-induced up-regulation of Mmp-3,Mmp-13 and Adamts-5 transcription.	price>
R-C-1642	GSK1940029 CAS：1150701-66-8	GSK1940029(SCD inhibitor 1)is a stearoyl-coa desaturas(SCD)inhibitor extracted from patent WO/2009060053 A1,compound example 16.	price>

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