Product apis-proteases

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Catalog	name	Description	price
R-C-1972	LSN3154567(Nampt-IN-1) CAS:1698878-14-6	Nampt-IN-1(LSN3154567)is a potent and selective NAMPT inhibitor.Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1nM.	price>
R-C-1973	CVT-12012 CAS：1018675-35-8	CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase(SCD)inhibitor, with IC50s of 38 nM,6.1nM for rat microsomal and human HEPG2.	price>
R-C-1989	Dibenzazepine (YO-01027) CAS：209984-56-5	Dibenzazepine（YO-01027 and Iminostilbene)is a potent γ-secretase inhibitor. Dibenzazepine also potently blocks amyloid precursor protein-like(APPL)and Notch cleavage.γ-Secretase is a fascinating,multi-subunit,intramembrane cleaving protease that is now being considered as a therapeutic target for a number of diseases.Potent,orally bioavailable γ-secretase inhibitors(GSIs)have been developed and tested in humans with Alzheimer is disease(AD)and cancer.	price>
R-C-2002	GSK805 CAS:1426802-50-7	GSK805 is a potent,orally bioavailable, and CNS penetrant RORγt inhibitor with pIC50 of 8.4 and>8.2 for RORγ FRET assay and Th17 assay.	price>
R-C-2018	Talabostat (Val-boroPro, PT-100) CAS：149682-77-9	Talabostat(Val-boroPro;PT100)is an orally active and nonselective dipeptidyl peptidase IV(DPP-IV)inhibitor(IC50<4 nM;Ki=0.18nM)and the first clinical inhibitor of fibroblast activation protein(FAP)(IC50=560nM).	price>
R-C-2023	AMG-3969 CAS：1361224-53-4	AMG-3969 is a potent glucokinase-glucokinase regulatory protein interaction(GK-GKRP)disruptor with an IC50 of 4nM.	price>
R-C-2028	CAY10650 CAS:1233706-88-1	CAY10650 is a highly potent cytosolic phospholipase A2α(cPLA2α)inhibitor with an IC50 value of 12nM.CAY10650 suppresses lipid droplets formation and PGE2 secretion.	price>
R-C-2045	C75 CAS：218137-86-1	C75 is a synthetic fatty-acid synthase(FASN)inhibitor;inhibits prostate cancer cells PC3 with an IC50 of 35μM.C75 is a potent CPT1A activator.	price>
R-C-2050	DO-264 CAS:2301866-59-9	DO-264 is a selective and in vivo-active inhibitor of Abhydrolase Domain Containing 12(ABHD12),with an IC50 of 11nM.	price>
R-C-2051	BTdCPU CAS:1257423-87-2	BTdCPU is an activator of HRI.The eIF2-alpha kinase HRI is a novel therapeutic target in multiple myeloma.Combination therapy with rapamycin,an mTOR inhibitor, and BTdCPU,an activator of HRI,demonstrated additive effects on apoptosis in dex-resistant cells.Thus,specific activation of the eIF2α kinase HRI is a novel therapeutic target in MM that can augment current treatment strategies.	price>

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