Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-3063	SB415286 CAS: 264218-23-7	SB415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β. SB415286 causes MM cell growth arrest and apoptosis.	price>
R-C-3064	LY2090314 CAS:603288-22-8	LY2090314 is a potent GSK-3 inhibitor for GSK-3α/β with IC50 of 1.5 nM/0.9 nM; may improve the efficacy of platinum-based chemotherapy regimens. LY2090314 is highly selective towards GSK3 as demonstrated by its fold selectivity relative to a large panel of kinases.	price>
R-C-3065	BX517 CAS:850717-64-5	BX517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).	price>
R-C-3066	GSK2334470 CAS:1227911-45-6	GSK2334470 is a novel PDK1 inhibitor with IC50 of ~10 nM in a cell-free assay, with no activity at other close related AGC-kinases.Only for scientific research, not for human body.	price>
R-C-3067	SL-0101-1 cas:77307-50-7	SL 0101-1 is a selective p90 ribosomal S6 kinase (RSK) inhibitor for RSK2 with an IC50 of 89 nM. The IC50 of kaempferol, the flavonoid constituent of SL 0101-1, is 15 μM for RSK. The rhamnose moiety of SL 0101-1 increases the affinity for RSK by >150-fold. Only for scientific research, not for human body.	price>
R-C-3068	BI-D1870 CAS:501437-28-1	BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.Only for scientific research, not for human body.	price>
R-C-3069	IM156 CAS: 1422365-93-2	IM156 (HL156A), a metformin derivative, is a potent activator of AMPK that increases AMPK phosphorylation. IM156 blocks oxidative phosphorylation (OXPHOS) through the inhibition of complex I and increases apoptosis. IM156 ameliorates various types of fibrosis and inhibits tumors.Only for scientific research, not for human body.	price>
R-C-3070	MK-3903 CAS：1219737-12-8	MK-3903 is a potent and selective AMPK activator with an EC50 of 8 nM for α1 β1 γ1 subunit. It activates 10 of the 12 pAMPK complexes with EC50 values in the range of 8-40 nM and maximal activation >50%.Only for scientific research, not for human body.	price>
R-C-3071	PF-06409577 CAS:1467057-23-3	PF-06409577 is orally bioavailable AMPK activator with EC50 of 7 nM for α1β1γ1 in the TR-FRET assay and it shows no detectable inhibition of hERG in a patch-clamp assay (100 μM) and was not an inhibitor (IC50 > 100 μM) of the microsomal activities of major human cytochrome P450 isoforms.Only for scientific research, not for human body.	price>
R-C-3072	OTSSP167 CAS:1431697-89-0	OTSSP167 (OTS167) is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM.Only for scientific research, not for human body.	price>

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