Product apis-pi3k-akt-mtor

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Catalog	name	Description	price
R-C-3052	INK 128 (MLN0128) CAS:1224844-38-5	INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.	price>
R-C-3053	GDC-0349 CAS:1207360-89-1	GDC-0349 is a potent and selective ATP-competitive inhibitor of mTOR with Ki of 3.8 nM, 790-fold inhibitory effect against PI3Kα and other 266 kinases.	price>
R-C-3054	WAY-600 CAS:1062159-35-6	WAY-600 is a single digit nanomolar inhibitor of the mTOR kinases, with significant selectivity for these enzymes over phosphatidylinositol 3-kinase (PI3K) isofoms (>100-fold).	price>
R-C-3055	WYE-687 CAS: 1062161-90-3	WYE-687 is an ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM; blocks mTORC1/pS6K(T389) and mTORC2/P-AKT(S473) but no effect observed on P-AKT(T308). Selectivity for mTOR is greater than PI3Kα (>100-fold) and PI3Kγ (>500-fold).	price>
R-C-3056	WYE-354 CAS:1062169-56-5	WYE-354 is a potent, specific and ATP-competitive inhibitor of mTOR with IC50 of 5 nM, blocks mTORC1/P-S6K(T389) and mTORC2/P-AKT(S473) not P-AKT(T308), selective for mTOR than PI3Kα (>100-fold) and PI3Kγ (>500-fold).	price>
R-C-3057	Ridaforolimus (Deforolimus, MK-8669) CAS:572924-54-0	Ridaforolimus (Deforolimus, MK-8669, AP23573) is a selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.	price>
R-C-3058	Paeoniflorin (NSC 178886) CAS:23180-57-6	Paeoniflorin (NSC 178886) is a herbal constituent extracted from the root of Paeonia albiflora Pall. Paeoniflorin reduces COX-2 expression. Paeoniflorin alleviates liver fibrosis by inhibiting HIF-1α through mTOR-dependent pathway.	price>
R-C-3059	HUN86320 CAS:882286-32-0	TSPC is an inhibitor for GA perception by in vitro and in planta evaluations.	price>
R-C-3060	BRD3731 cas:2056262-07-6	BRD3731 is a selective GSK3β inhibitor, with IC50s of 15 nM and 215 nM for GSK3β and GSK3α, respectively. BRD3731 inhibits the phosphorylation of CRMP2 in SH-SY5Y cells. BRD3731 decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation in HL-60 cells. BRD3731 impairs colony formation in TF-1 and increases colony forming ability in the MV4-11 cell line.	price>
R-C-3062	BRD0705 CAS:2056261-41-5	BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor.	price>

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