Product apis-nf-kb

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Catalog	name	Description	price
R-R-1279	Obtusifolin CAS No.477-85-0	Obtusifolin/CAS No.477-85-0, isolated from the seeds of Cassia obtusifolia, regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein.	price>
R-R-1280	5-Aminosalicylic acid-d3 CAS No.1309283-32-6	5-Aminosalicylic acid-d3/CAS No.1309283-32-6 is the deuterium labeled 5-Aminosalicylic Acid. 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.	price>
R-R-1281	SM-7368 CAS No.380623-76-7	SM-7368/CAS No.380623-76-7 is a potent NF-kB inhibitor that targets downstream of MAPK p38 activation. SM-7368 inhibits TNF-α-induced MMP-9 upregulation. SM-7368 can be used for the research of chemotherapies targeting TNF-α-mediated tumor invasion and metastasis .	price>
R-R-1282	12-Oxo phytodienoic acid CAS No.85551-10-6	12-Oxo phytodienoic acid (12-OPDA)/CAS No.85551-10-6 is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid suppresses neuroinflammation by inhibiting Nf-κB and p38 MAPK signaling in LPS-activated cells. 12-Oxo phytodienoic acid can be used for neurodegenerative diseases research.	price>
R-R-1283	Reticuline CAS No.485-19-8	Reticuline/CAS No.485-19-8 shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.	price>
R-R-1284	EN450 CAS No.793719-01-4	EN450/CAS No.793719-01-4 is a cysteine-reactive covalent molecular glue degrader targeting NF-κB. EN450 interacts with allosteric C111 in the E2 ubiquitin ligase UBE2D. EN450 induces the ternary complex formation between UBE2D and NFKB1. EN450 exerts its anti-proliferative effects through a Cullin E3 ligase and proteasome-dependent mechanism.	price>
R-R-1285	Neochlorogenic acid CAS No.906-33-2	Neochlorogenic acid/CAS No.906-33-2 is a natural polyphenolic compound found in dried fruits and other plants. Neochlorogenic acid inhibits the production of TNF-α and IL-1β. Neochlorogenic acid suppresses iNOS and COX-2 protein expression. Neochlorogenic acid also inhibits phosphorylated NF-κB p65 and p38 MAPK activation.	price>
R-R-1286	Cardamonin CAS No.18956-16-6	Cardamonin/CAS No.18956-16-6 can be found from cardamom, and target various signaling molecules, transcriptional factors, cytokines and enzymes. Cardamonin can inhibit mTOR, NF-κB, Akt, STAT3, Wnt/β-catenin and COX-2. Cardamonin shows anticancer, anti-inflammatory, antimicrobial and antidiabetic activities.	price>
R-R-1287	Suberosin CAS No.581-31-7	Suberosin/CAS No.581-31-7, isolated from Plumbago zeylanica, exhibits anti-inflammatory and anticoagulant activity. Suberosin suppresses PHA-induced PBMC proliferation and arrested cell cycle progression from the G1 transition to the S phase through the modulation of the transcription factors NF-AT and NF-κB.	price>
R-R-1288	Cynaropicrin CAS No.35730-78-0	Cynaropicrin/CAS No.35730-78-0 is a sesquiterpene lactone which can inhibit tumor necrosis factor (TNF-α) release with IC50s of 8.24 and 3.18 μM for murine and human macrophage cells, respectively. Cynaropicrin also inhibits the increase of cartilage degradation factor (MMP13) and suppresses NF-κB signaling.	price>

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