Product apis-nf-kb

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Catalog	name	Description	price
R-C-1540	TPCA-1 CAS:507475-17-4	TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation,DNA binding,and transactivation.	price>
R-C-1672	Adelmidrol CAS;1675-66-7	Adelmidrol exerts important anti-inflammatory effects that are partly dependent on PPARγ.Adelmidrol reduces NF-κB translocation,and COX-2 expression.	price>
R-C-1808	LY2409881 trihydrochloride CAS:946518-60-1	LY2409881 trihydrochloride is a selective IκB kinase β(IKK2)inhibitor with an IC50 of 30nM.	price>
R-C-1816	BAY11-7082 CAS:19542-67-7	BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor.BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α,and decreases NF-κB and expression of adhesion molecules.BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21(IC50=0.19,0.96μMrespectively).BAY 11-7082 inhibits gasdermin D(GSDMD)pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells.	price>
R-C-1834	BV6 CAS:1001600-56-1	BV6 is an inhibitor of apoptosis(IAP)proteins.It acts by promoting glioblastoma cancer stem-like cell differentiation by activating NF-κB.	price>
R-C-2253	Neferine CAS：2292-16-2	Neferine((R)-1,2-Dimethoxyaporphine),a natural component of Nelumbo nucifera, has antitumor efficiency,Neferine induces apoptosis in renal cancer cells. Neferine prevents autophagy through activation of Akt/mTOR pathway and Nrf2 in muscle cells.Neferine strongly inhibits NF-κB activation.	price>
R-C-2136	GSK8612 CAS：2361659-62-1	GSK8612 is a potent and highly selective TBK1 inhibitor.GSK8612 inhibited recombinant TBK1 with an average pIC50 of 6.8 in a biochemical functional assay. In THP1 cells,GSK8612 was able to inhibit secretion of interferon beta(IFNβ)in response to dsDNA and cGAMP,the natural ligand for STING.GSK8612 is a TBK1 small molecule inhibitor displaying an excellent selectivity profile and therefore represents an ideal probe to further dissect the biology of TBK1 in models of immunity,neuroinflammation,obesity,or cancer.	price>
R-C-2149	Bardoxolone Methyl CAS:218600-53-4	Bardoxolone Methyl(RTA 402,TP-155,NSC 713200,CDDO Methyl Ester,CDDO-Me)is an IKK inhibitor,showing potent proapoptotic and anti-inflammatory activities;Also a potent Nrf2 activator and nuclear factor-κB(NF-κB)inhibitor.Bardoxolone Methyl abrogates ferroptosis.Bardoxolone methyl induces apoptosis and autophagy in cancer cells.	price>
R-C-2152	Rocaglamide CAS: 84573-16-0	Rocaglamide(Rocaglamide A)is isolated from the genus Aglaia and can be used to treat coughs,injuries,asthma and inflammatory skin diseases.Rocaglamide is a potent inhibitor of NF-κB activation in T-cells.Rocaglamide is a potent and selective heat shock factor 1(HSF1)activation inhibitor with an IC50 of ~50nM.Rocaglamide inhibits the function of the translation initiation factor eIF4A.	price>
R-C-2155	Urolithin B CAS:1139-83-9	Urolithin B is a metabolite of the polyphenolic antioxidant ellagic acid that has diverse biological activities.It is formed from ellagic acid via several intermediates by gut microbiota.Urolithin B reduces the levels of advanced glycation end products(AGEs)in a cell-free assay in a concentration-dependent manner.Urolithin B(1.18-4.7nM)inhibits testosterone-induced proliferation of MCF-7aro cells.	price>

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