Product apis-nf-kb

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Catalog	name	Description	price
R-R-1379	Edasalonexent CAS No.1204317-86-1	Edasalonexent (CAT-1004)/CAS No.1204317-86-1 is an orally bioavailable NF-κB inhibitor.	price>
R-R-1380	AP-1/NF-kB activation inhibitor 1 CAS No.188936-12-1	AP-1/NF-κB activation inhibitor 1/CAS No.188936-12-1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.	price>
R-R-1381	(-)-DHMEQ CAS No.287194-40-5	(-)-DHMEQ (Dehydroxymethylepoxyquinomicin)/CAS No.287194-40-5 is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity.	price>
R-R-1382	Caffeic acid phenethyl ester CAS No.104594-70-9	Caffeic acid phenethyl ester/CAS No.104594-70-9 is a NF-κB inhibitor.	price>
R-R-1383	Flaconitine CAS No.77181-26-1	Flaconitine/CAS No.77181-26-1 is considered to be a NF-κB inhibitor. Flaconitine is a natural alkaloid compound found in the plant Aconitum ferox, also known as Indian aconite or Nepalese aconite. It is a highly toxic substance that can cause severe cardiac and neurological effects, and is often used as a poison in traditional medicine.	price>
R-R-1384	Helenalin CAS No.6754-13-8	Helenalin/CAS No.6754-13-8 is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding.	price>
R-R-1395	Karanjin CAS No.521-88-0	Karanjin/CAS No.521-88-0 is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research.	price>
R-R-1455	Pyridinium bisretinoid A2E TFA CAS No.1821308-73-9	Pyridinium bisretinoid A2E (A2E) TFA/CAS No.1821308-73-9 is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases.	price>
R-R-1507	(1S,2S)-Bortezomib CAS No.1132709-14-8	(1S,2S)-Bortezomib/CAS No.1132709-14-8 is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans.	price>
R-R-1554	Nargenicin A1 CAS No.70695-02-2	Nargenicin A1/CAS No.70695-02-2 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia.	price>

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