Product apis-nf-kb

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Catalog	name	Description	price
R-R-1379	Edasalonexent CAS No.1204317-86-1	Edasalonexent (CAT-1004)/CAS No.1204317-86-1 is an orally bioavailable NF-κB inhibitor.	price>
R-R-1380	AP-1/NF-kB activation inhibitor 1 CAS No.188936-12-1	AP-1/NF-κB activation inhibitor 1/CAS No.188936-12-1 is a potent AP-1 and NF-κB mediated transcriptional activation inhibitor (IC50=1 μM), without blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation inhibitor 1 has a similar inhibitory effect on the production of IL-2 and IL-8 levels in stimulated cells.	price>
R-R-1381	(-)-DHMEQ CAS No.287194-40-5	(-)-DHMEQ (Dehydroxymethylepoxyquinomicin)/CAS No.287194-40-5 is a potent, selective and irreversible NF-κB inhibitor that covalently binds to a cysteine residue. (-)-DHMEQ inhibits nuclear translocation of NF-κB and shows anti-inflammatory and anticancer activity.	price>
R-R-1382	Caffeic acid phenethyl ester CAS No.104594-70-9	Caffeic acid phenethyl ester/CAS No.104594-70-9 is a NF-κB inhibitor.	price>
R-R-1383	Flaconitine CAS No.77181-26-1	Flaconitine/CAS No.77181-26-1 is considered to be a NF-κB inhibitor. Flaconitine is a natural alkaloid compound found in the plant Aconitum ferox, also known as Indian aconite or Nepalese aconite. It is a highly toxic substance that can cause severe cardiac and neurological effects, and is often used as a poison in traditional medicine.	price>
R-R-1384	Helenalin CAS No.6754-13-8	Helenalin/CAS No.6754-13-8 is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding.	price>
R-R-1395	Karanjin CAS No.521-88-0	Karanjin/CAS No.521-88-0 is an orally active furanoflavonoid which can be isolated from several Leguminosae. Karanjin exhibits evident anti-diabetic, anti-cancer, anti-inflammatory, antioxidant, anticolitis, anti-ulcer, anti-Alzheimer properties and multiple insect repellent/insecticidal, acaricide properties, suggesting the potential of Karanjin to be applied to relevant research.	price>
R-R-1507	(1S,2S)-Bortezomib CAS No.1132709-14-8	(1S,2S)-Bortezomib/CAS No.1132709-14-8 is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans.	price>
R-R-1554	Nargenicin A1 CAS No.70695-02-2	Nargenicin A1/CAS No.70695-02-2 is an antibiotic agent against various Gram-positive bacteria. Nargenicin A1 shows anti-inflammatory activity. Nargenicin A1 protects HINAE cells against Tacrolimus (HY-13756)-induced DNA damage and apoptosis. Nargenicin A1 can also be used for the research of acute myeloid leukemia.	price>
R-R-1555	Curcumol CAS No.4871-97-0	Curcumol ((-)-Curcumol)/CAS No.4871-97-0, a bioactive sesquiterpenoid, possesses numerous pharmacological activities like anticancer, antimicrobial, antifungal, antiviral, and antiinflammatory. Curcumol is a potent inducer of apoptosis in numerous cancer cells via targeting key signaling pathways as MAPK/ERK, PI3K/Akt and NF-κB which are generally deregulated in several cancers.	price>

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