Product apis-nf-kb

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Catalog	name	Description	price
R-R-1559	Jaceosidin CAS No.18085-97-7	Jaceosidin/CAS No.18085-97-7 is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression. Jaceosidin exhibits anti-cancer, anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation.	price>
R-R-1592	Tylvalosin CAS No.63409-12-1	Tylvalosin (Acetylisovaleryltylo?sin)/CAS No.63409-12-1 is a broad-spectrum macrolide antibiotic that has antibacterial activity. Tylvalosin is an antiviral agent and can be used for PRRSV infection. . Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, relieves oxidative stress, and relieves acute lung injury by suppression of NF-κB activation.	price>
R-C-506	Laquinimod cas:248281-84-7	Laquinimod is a potent immunomodulator which prevents neurodegeneration and inflammation in the central nervous system.	price>
R-R-2299	DTP3 CAS No.1809784-29-9	DTP3 TFA/CAS No.1809784-29-9 is a potent and selective GADD45β/MKK7 inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.	price>
R-C-607	QNZ (EVP4593) cas:545380-34-5	QNZ(EVP4593)shows strong inhibitory effects on NF-κB transcriptional activation and TNF-αproduction with IC50s of 11 and 7 nM,respectively.QNZ (EVP4593) is a neuroprotective inhibitor of SOC channel.	price>
R-C-1097	Omaveloxolone (RTA-408) CAS:1474034-05-3	Omaveloxolone(RTA 408)is an antioxidant inflammation modulator(AIM),which activates Nrf2 and suppresses nitric oxide(NO).Omaveloxolone attenuates osteoclastogenesis by inhibiting STING dependent NF-κb signaling.	price>
R-C-1105	LY2409881 CAS：946518-60-1	LY2409881 is a selective inhibitor of IκB kinase β(IKK2;IC50=30 nM).1 It inhibits IKK1 and other common kinases at≥10-fold higher concentrations.1 LY2409881 has been shown to suppress constitutively activated NF-κB and to induce apoptosis in lymphoma cells both in vitro and in preclinical mouse models of B and T cell lymphoma both as a single agent and in combination with histone deacetylase inhibitors.	price>
R-R-2957	N-Salicyloyltryptamine CAS No.31384-98-2	N-Salicyloyltryptamine/CAS No.31384-98-2 acts on voltage-dependent Na+, Ca2+, and K+ ion channels inhibitor. N-Salicyloyltryptamine inhibits K+ currents with an IC50 value of 34.6 μM (Ito). N-Salicyloyltryptamine also exhibits anticonvulsant, anti-inflammatory, analgesic, and vasorelaxation effect-.	price>
R-C-1283	IKK16 CAS:873225-46-8	IKK-16(IKK Inhibitor VII)is a selective IκB kinase(IKK)inhibitor for IKK-2,IKK complex and IKK-1 with IC50 of 40 nM,70 nM and 200 nM in cell-free assays, respectively.IKK-16 also inhibits LRRK2 Ser935 phosphorylation in cells and LRRK2 kinase activity in vitro with IC50 of 50 nM.	price>
R-C-1336	PS-1145 CAS：431898-65-6	PS-1145 is a selective IκB kinase(IKK)inhibitor(IC50100 nM).PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells.PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha.PS1145 inhibited PC cell proliferation.PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats.	price>

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