Product apis-membranet-transporters

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Catalog	name	Description	price
R-C-1967	PF-06869206 CAS：2227425-05-8	PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2(SLC34A1)with an IC50 of 380nM.	price>
R-C-1971	GNE-131 CAS：1629063-81-5	GNE-131 is a Potent and Selective hNaV1.7 Inhibitor(Na V1.7 IC50 =3nM)for the Treatment of Pain.GNE-131 showed excellent potency,good in vitro metabolic stability,and low in vivo clearance in mouse,rat and,dog.GNE-131 also displayed excellent efficacy in a transgenic mouse model of induced pain.	price>
R-C-2020	Zuranolone(sage217) CAS：1632051-40-1	Zuranolone is an orally active and potent neuroactive steroid positive allosteric modulator of GABAA receptor,with EC50s of 296 and 163nM for α1β2γ2 and α4β3δ GABAA receptors,respectively.	price>
R-C-2024	IC-87201 CAS：866927-10-8	IC87201,an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation.	price>
R-C-2047	Org 25543 hydrochloride cas:495076-64-7	Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2)inhibitor for hGlyT2.Two major subtypes of glycine transporter are type 1(GlyT-1)and type 2(GlyT-2)revealed by molecular cloning.The GlyT-2 transporter has a similar distribution to ssGlyR with being confined to the spinal cord and brain stem,whereas the GlyT-1 transporter has a wide distribution throughout the CNS.	price>
R-C-2058	Nelonicline CAS:1026134-63-3	Nelonicline(ABT-126)is an Alpha7 nicotinic acetylcholine receptor agonist and Nicotinic acetylcholine receptor agonist.Nelonicline is potentially useful for the treatment of Alzheimer is diseases.ABT-126 may be useful to reduce dyskinesias in both early-and later-stage Parkinson is disease.Accumulating evidence suggests that the α7 subtype of nicotinic acetylcholine receptors (nAChRs)plays a key role in inflammatory processes,thought to be involved in the pathophysiology of neuropsychiatric diseases,such as schizophrenia and Alzheimer is disease.	price>
R-C-2094	PF06869206 CAS：2227425-05-8	PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a(SLC34A1)with an IC50 of 380nM.	price>
R-C-2096	ONO-8590580 CAS：1802661-73-9	ONO-8590580 is a GABAAα5 negative allosteric modulator which enhances long-term potentiation and improves cognitive deficits in preclinical models.	price>
R-C-2099	(-)-(S)-B973B CAS：2244989-34-0	(-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR,with antinociceptive activity.	price>
R-C-2297	Cilnidipine (FRC-8653) CAS:132203-70-4	Cilnidipine(FRC-8653)is a calcium channel blocker.Cilnidipine is the novel calcium antagonist accompanied with L-type and N-type calcium channel blocking function.It was approved in 1995.Compared with other calcium antagonists,cilnidipine can act on the N-type calcium channel that existing sympathetic nerve end besides acting on L-type calcium channel that similar to most of the calcium antagonists.	price>

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