Product apis-membranet-transporters

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Catalog	name	Description	price
R-C-1656	pipequaline CAS:77472-98-1	Pipequaline(PK 8165)is a partial benzodiazepine receptor agonist with anxiolytic activity.	price>
R-C-1668	SB366791 CAS：472981-92-3	SB-366791 is a potent，competitive and selective vanilloid receptor(VR1/TRPV1) antagonist with IC50 of 5.7 1.2nM target:VR1/TRPV1 IC 50:5.7±1.2 nM[1]SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08.	price>
R-C-1748	AM2099 CAS：1443373-17-8	AM-2099 is a potent and selective inhibitor of voltage-gated sodium channel Nav1.7 with an IC50 of 0.16μM for human Nav1.7.	price>
R-C-1790	S0859 CAS：1019331-10-2	S0859,an N-cyanosulphonamide compound,reversibly inhibit NBC-mediated pH(i) recovery(K(i)=1.7 microM,full inhibition at approximately 30 microM).	price>
R-C-1807	Eniporide CAS:176644-21-6	ENIPORIDE is a potent Na+/H+ exchange inhibitor.	price>
R-C-1814	AT-007 CAS: 2170729-29-8	AT-007 is an orally active central nervous system(CNS)penetrant Aldose Reductase inhibitor for treatment of Galactosemia with an IC50 value of 100 pM.AT-007 reduces toxic galactitol levels and prevents disease complications in GALT deficiency rats.	price>
R-C-1848	PST-2744 (Istaroxime) CAS：203737-94-4,203737-93-3	Istaroxime（PST-2744)is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase(Na+/K+ ATPase). Na+/K+ATPase inhibition increases intracellular sodium levels,which reverses the driving force of the sodium/calcium exchanger,inhibiting calcium extrusion and possibly facilitating calcium entry.	price>
R-C-1897	Valbenazine CAS:1025504-45-3	Valbenazine（NBI-98854 and MT-5199)is a potent and selective VMAT2 inhibitor. NBI-98854 is effective in regulating the levels of dopamine release during nerve communication,while at the same time having minimal impact on the other monoamines.NBI-98854 is promising agent for the treatment of tardive dyskinesia.NBI-98854 significantly improved tardive dyskinesia and was well tolerated in patients.These results support the phase 3 clinical trials of NBI-98854 now underway.	price>
R-C-1942	IK1 inhibitor PA-6 CAS：500715-03-7	IK1 inhibitor PA-6(PA-6),a pentamidine analogue,is a selective and potent IK1(KIR2.x ion-channel-carried inward rectifier current)inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents.IK1 inhibitor PA-6(PA-6)elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation.IK1 inhibitor PA-6(PA-6)has the potential to treat atrial fibrillation and arrhythmia.	price>
R-C-1946	QNZ46 CAS:1237744-13-6	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist(IC50 values are 3,6,229,and>300,>300μM for NR2D,NR2C,NR2A,NR2B,and GluR1, respectively).	price>

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