Product apis-membranet-transporters

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Catalog	name	Description	price
R-C-2299	Amlodipine maleate CAS:88150-47-4	Amlodipine maleate is a dihydropyridine calcium channel blocker,acts as an orally active antianginal agent.Amlodipine maleate blocks the voltage-dependent L-type calcium channels,thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer.	price>
R-C-2303	Felodipine CAS:72509-76-3	Felodipine,a dihydropyridine,is a potent,vasoselective calcium channel antagonist.Felodipine lowers blood pressure(BP)by selective action on vascular smooth muscle,especially in the resistance vessels.Felodipine,an anti-hypertensive agent,induces autophagy.Felodipine can cross the blood-brain barrier.	price>
R-C-2315	YM-58483 (BTP2) CAS:223499-30-7	YM-58483(BTP2)is the first selective and potent inhibitor of CRAC channels and subsequent Ca2+ signals.YM-584832 is a blocker of store-operated Ca2+entry(SOCE).	price>
R-C-2336	Gramine CAS:87-52-5	Gramine(Donaxine)is a natural alkaloid isolated from giant reed,acts as an active adiponectin receptor(AdipoR)agonist,with IC50s of 3.2 and 4.2µM for AdipoR2 and AdipoR1,respectively.Gramine is also a human and mouse β2-Adrenergic receptor(β2-AR)agonist.Gramine(Donaxine)has anti-tumor,anti-viral and anti-inflammatory properties.	price>
R-C-2456	benzylquinolone carboxylic acid CAS：338747-41-4	BQCA(benzylquinolone carboxylic acid)is a highly selective positive allosteric modulator of the M1 muscarinic acetylcholine receptor(mAChR).	price>
R-C-2500	AZD9056 hydrochloride CAS ：345303-91-5	AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.	price>
R-C-2549	Elacridar HCl CAS:143851-98-3	Elacridar(GF120918A)is a P-glycoprotein(P-gp)inhibitor,and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein(Pgp)to investigate the role of transporters in the disposition of various test molecules.In vitro, GF120918A demonstrated high plasma protein binding across species,although a definitive protein binding evaluation was precluded by poor recovery, particularly in buffer and in mouse,rat,and dog plasma.GF120918A did not demonstrate potent inhibition of several human cytochrome P450 enzymes evaluated in vitro,with IC(50)values well above concentrations anticipated to be achieved in vivo.Together,these data confirm the utility of GF120918A as a tool P-glycoprotein inhibitor in preclinical species and offer additional guidance on preclinical dose regimens likely to produce P-glycoprotein-mediated effects.	price>
R-C-3182	PF 3716556 CAS:928774-43-0	PF 3716556 is a potent and selective P-CAB(potassium-competitive acid blocker),with pIC50 of 6.026 and 7.095 for the inhibition of porcine H+,K+-ATPase activity in ion-leaky and ion-tight assay,respectively,inhibits gastric acid secretion,displays no activity at Na+,K+-ATPase.	price>
R-C-3183	Bufalin CAS:465-21-4	Bufalin(BF)is a potent inhibitor of steroid receptor coactivator SRC-3,SRC-1 and Na+/K+-ATPase. Bufalin binds to the subunit α1,α2 and α3 of Na+/K+-ATPase with Kd of 42.5 nM, 45 nM and 40 nM, respectively.	price>
R-C-3184	PPQ-102 CAS:931706-15-9	PPQ-102(CFTR Inhibitor IV)is a potent inhibitor of CFTR.PPQ-102 can completely inhibit CFTR chloride current with IC50 of ~90nM.	price>

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