Product apis-membranet-transporters

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Catalog	name	Description	price
R-C-1293	NS 11021 CAS:956014-19-0	NS-11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa,KCa1.1).BK channel activation by NS11021 decreases excitability and contractility of urinary bladder smooth muscle.NS11021 enhances erectile responses in rats.	price>
R-C-1294	KO143 CAS:461054-93-3	Ko 143 is a potent and selective ATP-binding cassette subfamily G member 2 (ABCG2/BCRP)inhibitor.Ko 143 displays>200-fold selectivity over P-gp and MRP-1 transporters.	price>
R-C-1320	CB5083 CAS:1542705-92-9	CB-5083 is a novel first in class,potent orally bio-available p97 inhibitor that disrupts cellular protein homeostasis and demonstrates anti-tumor activity in solid and hematological models.	price>
R-C-1321	SYM2206 CAS:173952-44-8	SYM2206 is a potent and non-competitive AMPA receptor antagonist,with an IC50 of 1.6 μM.SYM2206 blocks Nav1.6-mediated persistent currents.	price>
R-C-1405	ML-277 CAS:1401242-74-7	ML277(CID53347902)is a novel,potent and selective K(v)7.1(KCNQ1)potassium channel activator with EC50 of 270 nM.	price>
R-C-1526	ABT-639 CAS:1235560-28-7	ABT-639 is a potent and selective T-type calcium channel blocker.ABT-639 effectively reduces nociceptive and neuropathic pain in rats.ABT-639 produces robust antinociceptive activity in experimental pain models at doses that do not significantly alter psychomotor or hemodynamic function in the rat.ABT-639 was significantly less active at other Ca²⁺channels(e.g.Ca(v)1.2 and Ca(v)2.2) (IC50>30μM).ABT-639 has high oral bioavailability(%F=73),low protein binding(88.9%)and a low brain:plasma ratio(0.05:1)in rodents.	price>
R-C-1554	PNU282987HCL CAS:123464-89-1	PNU282987 is a drug that acts as a potent and selective agonist for the α7 subtype of neural nicotinic acetylcholine receptors.In animal studies,it shows nootropic effects,and derivatives may be useful in the treatment of schizophrenia,although PNU-282,987 is not suitable for use in humans because of excessive inhibition of the hERG antitarget.	price>
R-C-1616	A804598 CAS:1125758-85-1	A-804598 is a CNS penetrant,competitive and selective P2X7 receptor antagonist with IC50s of 9 nM,10nM and 11 nM for mouse,rat and human P2X7 receptors, respectively.	price>
R-C-1649	SKF96365.HCl CAS:130495-35-1	SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca2+ entry(SOCE)inhibitor.SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1,hKir2.1 and hKv4.3 current,and significantly prolongs the QTc interval in isolated guinea pig hearts.SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.	price>
R-C-1652	DAA1106 CAS：220551-92-8	DAA1106 is a potent and selective ligand for peripheral benzodiazepine receptor (PBR),as a potent and selective agonist at the peripheral benzodiazepine receptor.	price>

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