Product apis-membranet-transporters

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Catalog	name	Description	price
R-C-1021	Ivacaftor (VX-770) CAS NO. 873054-44-5	Ivacaftor(VX-770)is a potent and orally bioavailable small molecule potentiator of cystic fibrosis transmembrane conductance regulator(CFTR).Studies in both G551D-and F508del-CFTR expressing cells have shown VX-700 combined with forskolin,but not VX-700 alone,has significantly increased CFTR-mediated Cl-secretion.The EC50 values of VX-700 in G551D- and F508del-CFTR are 100 nM and 25 nM,respectively.	price>
R-C-1042	Lomitapide (AEGR-733, BMS-201038） CAS No. 182431-12-5	Lomitapide is a small-molecule,microsomal triglyceride transfer protein(MTP) inhibitor,for the treatment of both familial and primary hypercholesterolemia. Oral,once-daily lomitapide will be targeted at patients resistant to HMG-CoA reductase inhibitors(statins)either due to abnormalities in liver function or to discontinuation because of muscle pain.	price>
R-C-1044	p7c3-a20 CAS:1235481-90-9	P7C3-A20 is a derivative of P7C3that has proneurogenic and neuroprotective activity.It increases proliferation in the subgranular zone(SGZ)of the adult mouse dentate gyrus in a dose-dependent manner when administered at doses ranging from 0.1 to 10 µM.It also protects U2OS cells from calcium-induced mitochondrial dissolution.In a rat model of traumatic brain injury,P7C3-A20 decreases contusion volume,increases proliferation in the SGZ,and decreases the latency to reach the platform in the Morris water maze to sham surgery control levels.It also prevents or reverses dopaminergic cell death and motor deficits in a 6-OHDA rat model of Parkinson disease.	price>
R-C-1067	7-ACC2 CAS:1472624-85-3	7ACC2 is a potent monocarboxylate transporter(MCT)inhibitor with an IC50 of 11 nM for inhibition of[14C]-lactate influx.7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport.7ACC2 is an anticancer agent through inhibition of lactate flux.	price>
R-C-1147	ML204 CAS：5465-86-1	ML204 is a novel,potent,and selective TRPC4 channel inhibitor with apparent IC50 values of about 1 μM in fluorescent intracellular Ca2+ assays and about 3 μM in whole-cell voltage clamp experiments.It exhibits some selectivity within the TRPC subfamily of channels and higher selectivity against other TRP channels and non-TRP channels.	price>
R-C-1182	NS6180	NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50=9nM) prevents T-cell activation and inflammation.	price>
R-C-1191	CP465022HCl CAS:199655-36-2	CP-465022 is a potent,and selective noncompetitive AMPA receptor antagonist.It provides neuroprotective efficacy after cerebral ischemia on the basis of the activity in experimental ischemia models.	price>
R-C-1192	RQ-00203078 CAS:1254205-52-1	RQ-00203078 is a highly selective,potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits>350-fold selectivity for TRPM8 over TRPV4,TRPV1 and TRPA1.	price>
R-C-1222	GS967 CAS：1262618-39-2	GS967 is a novel,potent,and selective inhibitor of cardiac late sodium current(late INa);inhibits ATX-II-induced late I(Na)in ventricular myocytes and isolated hearts with IC(50)values of 0.13 and 0.21 uM,respectively.	price>
R-C-1277	CK 1827452 CAS：873697-71-3	Omecamtiv mecarbil, also known as CK-1827452,is a cardiac specific myosin activator.It is clinically tested for its role in the treatment of left ventricular systolic heart failure.Omecamtiv Mecarbil specifically targets and activates myocardial ATPase and improves energy utilization.Omecamtiv Mecarbil improves systolic function by increasing the systolic ejection duration/stroke volume,without consuming more ATP energy,oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency.	price>

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