Ivacaftor (VX-770) CAS NO. 873054-44-5

Ivacaftor(VX-770)is a potent and orally bioavailable small molecule potentiator of cystic fibrosis transmembrane conductance regulator(CFTR).Studies in both G551D-and F508del-CFTR expressing cells have shown VX-700 combined with forskolin,but not VX-700 alone, has significantly increased CFTR-mediated Cl-secretion.The EC50 values of VX-700 in G551D- and F508del-CFTR are 100 nM and 25 nM,respectively.

msds---Ivacaftor (VX-770)