Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3533	Rolofylline CAS No.136199-02-5	Rolofylline (KW-3902)/CAS No.136199-02-5 is a potent, selective adenosine A1 receptor antagonist that is under development for the treatment of patients with acute congestive heart failure and renal impairment. Rolofylline is metabolized primarily to the pharmacologically active M1-trans and M1-cis metabolites by cytochrome P450 (CYP450). Rolofylline is alleviating the presynaptic dysfunction and restores neuronal activity as well as dendritic spine levels in vitro, is an interesting candidate to combat the hypometabolism and neuronal dysfunction associated with Tau-induced neurodegenerative diseases.	price>
R-R-3534	Taminadenant CAS No.1337962-47-6	Taminadenant (NIR178; PBF509)/CAS No.1337962-47-6 is a highly potent and orally active adenosine A2A receptor (A2AR) antagonist. Taminadenant can antagonize A2AR agonist-mediated cAMP accumulation and impedance responses with KB values of 72.8 nM and 8.2 nM, respectively. Taminadenant reverses motor impairments in several rat models of movement disorders, including catalepsy, tremor, and hemiparkinsonism. Taminadenant can also inhibit tumor growth when combined with Spartalizumab (HY-P9972). Taminadenant reactivate the antitumor immune response.	price>
R-R-3535	Doxofylline CAS No.69975-86-6	Doxofylline/CAS No.69975-86-6 is an orally active PDE IV inhibitor and A1AR antagonist. Doxofylline reduces inflammation in epithelial cells via inhibiting mitochondrial ROS production and amelioration of multiple cellular pathways (NLRP3-TXNIP inflammasome activation). Doxophylline can be used in studies of asthma, chronic obstructive pulmonary disease, and bronchospasm.	price>
R-R-3536	GS-6201 CAS No.752222-83-6	GS-6201 (CVT-6883)/CAS No.752222-83-6 is a selective adenosine A2B receptor antagonist. GS-6201 displays high affinity and selectivity for the human adenosine A2B receptors (Ki=22 nM). GS-6201 reduces caspase-1 activity in the heart, and attenuates cardiac remodeling after acute myocardial infarction (AMI) in the mouse. GS-62013 attenuates the airway reactivity induced by NECA, AMP, or allergen in sensitized mice.	price>
R-R-3537	LAS101057 CAS No.925676-48-8	LAS101057/CAS No.925676-48-8 is a potent, selective, and orally efficacious A2B receptor antagonist.	price>
R-R-3538	Tozadenant CAS No.870070-55-6	Tozadenant/CAS No.870070-55-6 is an adenosine A2A receptor antagonist, with Ki of 11.5 nM on human A2A and 6 nM on rhesus A2A.	price>
R-R-3539	N6-Ethyladenosine CAS No.14357-08-5	N6-Ethyladenosine/CAS No.14357-08-5 is an adenosine derivative, acts as a Adenosine receptor agonist, with Kis of 4.9 and 4.7 nM for hA1AR and hA3AR, respectively.	price>
R-R-3540	N6-(2-Phenylethyl)adenosine CAS No.20125-39-7	N6-(2-Phenylethyl)adenosine (N6-Phenethyladenosine)/CAS No.20125-39-7, an adenosine derivative, is a potent adenosine receptors (AR) agonist with Ki values of 11.8 nM, 30.1 nM, 0.63 nM for rat A1AR, human A1AR and hA3AR, respectively.	price>
R-R-3541	DPTN dihydrochloride CAS No.325767-87-1	DPTN/CAS No.325767-87-1 is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively.	price>
R-R-3542	M1069	M1069 is a selective and orall active, dual A2A/A2B adenosine receptor antagonist with a selectivity of >100 fold against the A1 and A3 receptors. M1069 counteracts immune-suppressive mechanisms of adenosine, and exhibits anti-tumor activity.	price>

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