Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3523	PSB-603 CAS No.1092351-10-4	PSB-603/CAS No.1092351-10-4 is a potent and highly selective A2B adenosine receptor antagonist exhibiting a Ki value of 0.553 nM and virtually no affinity for the human and rat A1 and A2A and the human A3 receptors up to a concentration of 10 μM.	price>
R-R-3524	SCH442416 CAS No.316173-57-6	SCH442416/CAS No.316173-57-6 is a potent, selective and brain-penetrant antagonist of adenosine A2A receptor (A2AR), with Kis of 0.048 and 0.5 nM for human and rat A2AR respectively. SCH442416 displays more than 23000-fold selectivity over A1R, A2BR, and A3R (Ki=1111, 10000, and 10000 nM, respectively). SCH442416 can be used for imaging of adenosine A2A receptors in rat and primate brain.	price>
R-R-3525	Nitrobenzylthioinosine CAS No.38048-32-7	Nitrobenzylthioinosine/CAS No.38048-32-7 is an ENT1 transporter inhibitor that binds to ENT1 transporter with high affinity. Nitrobenzylthioinosine is a photoaffinity probe for adenosine uptake sites in brain. Nitrobenzylthioinosine can cross the blood-brain barrier.	price>
R-R-3526	N6-Cyclopentyladenosine CAS No.41552-82-3	N6-Cyclopentyladenosine (CPA)/CAS No.41552-82-3 is a selective Adenosine A1 receptor agonist, with Ki values of 2.3 nM, 790 nM and 43 nM for human A1, A2A and A3 receptors, respectively.	price>
R-R-3527	MRS-1706 CAS No.264622-53-9	MRS-1706/CAS No.264622-53-9 is a potent and selective adenosine A2B receptor inverse agonist. MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1 and A3 receptors respectively. MRS-1706 blocks adenosine-mediated cAMP induction.	price>
R-R-3528	MRS-1191 CAS No.185222-90-6	MRS-1191/CAS No.185222-90-6 is a potent and selective A3 adenosine receptor antagonist with a KB value of 92 nM, a Ki value of 31.4 nM for human A3 receptor and an IC50 of 120 nM for CHO cells. MRS-1191 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.	price>
R-R-3529	Inupadenant CAS No.2246607-08-7	Inupadenant/CAS No.2246607-08-7 is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity.	price>
R-R-3530	MRS 1523 CAS No.212329-37-8	MRS 1523/CAS No.212329-37-8 is a potent and selective adenosine A3 receptor antagonist with Ki values of 18.9 nM and 113 nM for human and rat A3 receptors, respectively. In rat this corresponds to selectivities of 140- and 18-fold vs A1 and A2A receptors, respectively. MRS 1523 can exert antihyperalgesic effect through N-type Ca channel block and action potential inhibition in isolated rat dorsal root ganglion (DRG) neurons.	price>
R-R-3531	CGS 15943 CAS No.104615-18-1	CGS 15943/CAS No.104615-18-1 is an orally bioavailable non-xanthine Adenosine Receptor antagonist. Its Ki for human A1, A2A, A2B, and A3 Adenosine Receptors are 3.5, 4.2, 16, and 50 nM in transfected CHO cells, respectively.	price>
R-R-3532	Tonapofylline CAS No.340021-17-2	Tonapofylline (BG 9928)/CAS No.340021-17-2 is an orally active and selective adenosine A1 receptor antagonist with a Ki of 7.4 nM for human adenosine A1 receptor (hA1), which displays 915-fold selectivity versus human adenosine A2A receptor and 12-fold selectivity versus human adenosine A2B receptor and is used in development for the treatment of heart failure.	price>

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