Product apis-gpcr-g-protein

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Catalog	name	Description	price
R-R-3346	(S)-Amisulpride CAS No.71675-92-8	(S)-Amisulpride (Esamisulpride)/CAS No.71675-92-8 is a potent dopamine D2/D3 receptor antagonist. (S)-Amisulpride is an antagonist at the 5-HT7 receptor with a KI of 900 nM. (S)-Amisulpride has antipsychotic and antidepressant effects.	price>
R-R-3347	SB228357 CAS No.181629-93-6	SB228357/CAS No.181629-93-6 is a selective, potent and orall active 5-HT2C/2B receptor antagonist with pKi values of 6.9, 8.0 and 9.0 for 5-HT2A, 5-HT2B and 5-HT2C, respectively. SB228357 has antidepressant/anxiolytic effects.	price>
R-R-3348	SB-200646A CAS No.143797-62-0	SB-200646A/CAS No.143797-62-0 is the first selective 5-HT2B/2C over 5-HT2A receptor antagonist with pKi values of 7.5, 6.9 and 5.2 for 5-HT2B, 5-HT2C and 5-HT2A, respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo.	price>
R-R-3349	PU02 CAS No.313984-77-9	PU02/CAS No.313984-77-9, a derivative of 6-MP (HY-13677), is a negative allosteric modulator (NAM) of 5-HT3 receptor, with IC50 values of 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.	price>
R-R-3350	Alniditan dihydrochloride CAS No.155428-00-5	Alniditan (Alnitidan) dihydrochloride/CAS No.155428-00-5 is a potent 5-HT1B and 5-HT1D receptors agonist, with IC50s of 1.7 nM and 1.3 nM for h5-HT1B and h5-HT1D receptors in HEK 293 cells, respectively. Alniditan dihydrochloride has migraine-preventive effects.	price>
R-R-3351	Tedatioxetine hydrobromide CAS No.960151-65-9	Tedatioxetine (Lu AA24530) hydrobromide/CAS No.960151-65-9 acts as a serotonin and norepinephrine (NE)-preferring triple reuptake inhibitor (TRI) and 5-HT2A, 5-HT2C, 5-HT3 and α1A-adrenergic receptor antagonist.	price>
R-R-3352	Naluzotan CAS No.740873-06-7	Naluzotan/CAS No.740873-06-7 is a novel, potent, and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM, used for the treatment of anxiety and depression; Also a weak hERG K+ channel blocker, with IC50 of 3800 nM.	price>
R-C-1653	Eptapirone (F11440) CAS：179756-58-2	Eptapirone(F11440)is a potent,selective,high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential.	price>
R-R-3353	Velusetrag hydrochloride CAS No.866933-51-9	Velusetrag (TD-5108) hydrochloride/CAS No.866933-51-9 is an orally active, potent and selective agonist of serotonin 5-HT4 receptor (5-HT4R), with a pKi of 7.7. Velusetrag hydrochloride exhibits no affinity (Ki>10 μM) for 5-HT2A and 5-HT2B receptors.	price>
R-C-1654	Orexin 2 Receptor Agonist CAS：1796565-52-0	Orexin 2 Receptor Agonist is a potent(EC50 on OX2R is 23nM)and OX2R-selective (OX1R/OX2R EC50 ratio is 70) agonist.	price>

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