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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4423 SAE-14 CAS No.1241280-25-0 SAE-14 (compound SAE-14)/CAS No.1241280-25-0 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. price>
R-R-4424 GPR183 antagonist-2 CAS No.2924063-98-7 GPR183 antagonist-2 (compound 32)/CAS No.2924063-98-7 is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases. price>
R-C-2748 PF-04971729(Ertugliflozin) CAS:1210344-57-2 Ertugliflozin(PF-04971729)is a potent,selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2),with an IC50 of 0.877nM for h-SGLT2.Has the potential for the treatment of type 2 diabetes mellitus. price>
R-C-2776 Ebrotidine CAS:100981-43-9 Ebrotidine(FI 3542)is a competitive H2-receptor antagonist(Ki=27.5nM)with a potent antisecretory activity and evidenced gastroprotection. price>
R-C-2777 CY 208-243 CAS：100999-26-6 CY 208-243 is a drug which acts as a dopamine agonist selective for the D1subtype.Unlike most D1-selective agonists,it shows efficacy in animal models of Parkinson is disease. price>
R-C-2780 Otenzepad (AF-DX 116) CAS：102394-31-0 Otenzepad(AF-DX 116)is a selective and competitive M2 muscarinic acetylcholine receptor antagonist,with IC50 values of 640nM and 386nM for rabbit peripheral lung and rat heart,respectively. price>
R-C-2781 VUF 10460 CAS：1028327-66-3 VUF10460 is a non-imidazole histamine H4 receptor agonist;binds to rat H4 receptor with a pKi of 7.46. price>
R-C-2792 TCN 238 CAS:125404-04-8 TCN238 is an orally bioavailable mGlu4 receptor positive allosteric modulator (PAM)with an EC50 of 1μM. price>
R-C-2797 L-732,138 CAS:148451-96-1 L-732138 is a selective,potent and competitive neurokinin-1(NK-1)receptor antagonist with an IC50 of 2.3nM.L-732138 has 200-fold more potent in cloned human NK-1 receptors than cloned rat NK-1 receptors,and has>1000-fold more potent than human NK-2 and NK-3 receptors.L-732138 can reduce hyperalgesia and has antitumor action. price>
R-C-2800 GR 103691 CAS:162408-66-4 GR 103691 is a potent,selective dopamine D3 receptor antagonist with a Ki value of 0.4nM.GR 103691 shows more than 100-fold selectivity for human dopamine human(h)D3 over hD4 and hD1 sites. price>