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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4416 Molindone-d8 CAS No.1189805-13-7 Molindone-d8/CAS No.1189805-13-7 is the deuterium labeled Molindone. Molindone hydrochloride (EN-1733A) is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses. price>
R-R-4417 Raclopride-d5 hydrochloride CAS No.1217623-85-2 Raclopride-d5 (hydrochloride)/CAS No.1217623-85-2 is the deuterium labeled Raclopride. Raclopride is a dopamine D2/D3 receptor antagonist, which binds to D2 and D3 receptors with dissociation constants (Kis) of 1.8 nM and 3.5 nM, respectively, but has a very low affinity for D1 and D4 receptors with Kis of 18000 nM and 2400 nM, respectively. price>
R-R-4418 Quetiapine-d8 fumarate CAS No.1185247-12-4 Quetiapine-d8 (fumarate)/CAS No.1185247-12-4 is the deuterium labeled Quetiapine. Quetiapine is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects. price>
R-R-4419 A-437203 CAS No.220519-06-2 A-437203/CAS No.220519-06-2 is a selective D3 receptor antagonist with Ki of 71, 1.6, and 6220 nM for D2, D3, and D4 receptors, respectively. price>
R-R-4420 7a,25-Dihydroxycholesterol CAS No.64907-22-8 7α, 25-dihydroxycholesterol (7α,25-OHC)/CAS No.64907-22-8 is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells. price>
R-R-4421 GSK682753A CAS No.1334294-76-6 GSK682753A/CAS No.1334294-76-6 is a selective and highly potent inverse agonist of the epstein-barr virus-induced receptor 2 (EBI2) with an IC50 of 53.6 nM. price>
R-R-4422 ML401 CAS No.1597489-14-9 ML401/CAS No.1597489-14-9, a potent chemical probe, selectively antagonizes EBI2 (also known as GPR183) with an IC50 of 1.03 nM. ML401 displays activity in a chemotaxis assay (IC50=6.24 nM). ML401 shows good stability and no toxicity. price>
R-R-4423 SAE-14 CAS No.1241280-25-0 SAE-14 (compound SAE-14)/CAS No.1241280-25-0 is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice. price>
R-R-4424 GPR183 antagonist-2 CAS No.2924063-98-7 GPR183 antagonist-2 (compound 32)/CAS No.2924063-98-7 is a selective GPR183 antagonist with good water solubility and excellent pharmacokinetic properties. GPR183 antagonist-2 significantly reduces paw and joint swelling and gene expression of pro-inflammatory cytokines (MCP-1, MMPs, and VEGF) in a collagen-induced arthritis (CIA) mouse model in a dose-dependent manner. GPR183 antagonist-2 can be used in the study of autoimmune diseases. price>
R-C-2748 PF-04971729(Ertugliflozin) CAS:1210344-57-2 Ertugliflozin(PF-04971729)is a potent,selective and orally active inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2),with an IC50 of 0.877nM for h-SGLT2.Has the potential for the treatment of type 2 diabetes mellitus. price>