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Catalog name Description price
R-R-4327 Eticlopride hydrochloride CAS No.97612-24-3 Eticlopride hydrochloride/CAS No.97612-24-3, a selective dopamine D2‐like receptor antagonist, exhibits high affinity for dopamine D2, α1‐adrenergic, α2‐adrenergic, 5HT1, 5HT2 receptors with Kis of 0.09, 112, 699, 6220, and 830 nM, respectively. Antipsychotic agent. price>
R-R-4328 Azaperone CAS No.1649-18-9 Azaperone (R-1929)/CAS No.1649-18-9 acts as a dopamine antagonist but also has some antihistaminic and anticholinergic properties. Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic agent with antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine. price>
R-R-4329 (±)-Levomepromazine-d6 CAS No.1189805-51-3 (±)-Levomepromazine-d6/CAS No.1189805-51-3 is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist. price>
R-R-4330 UCSF924 CAS No.1434515-70-4 UCSF924/CAS No.1434515-70-4 is a potent and specific dopamine D4 receptor (DRD4) partial agonist with a EC50 of 4.2 nM. UCSF924 has a high-affinity with a Ki value of 3 nM for DRD4 and shows no measurable affinity for D2, D3 or the F261V/L328F D4 mutant. UCSF924 is a 7.4-fold bias toward arrestin over Gαi/o signaling, referenced to quinpirole. price>
R-R-4331 SKF 83959 CAS No.80751-85-5 SKF83959/CAS No.80751-85-5 is a potent and selective dopamine D1-like receptor partial agonist. SKF83959 Ki values for rat D1, D5, D2 and D3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. price>
R-R-4332 Roxindole hydrochloride CAS No.108050-82-4 Roxindole hydrochloride (EMD 38362)/CAS No.108050-82-4, an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities. price>
R-R-4333 3-O-Methyldopa-d3 CAS No.586954-09-8 3-O-Methyldopa-d3/CAS No.586954-09-8 is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine. price>
R-R-4334 UNC9995 CAS No.1354030-52-6 UNC9995/CAS No.1354030-52-6 is a β-arrestin2-biased agonist of dopamine receptor Drd2. UNC9995 inhibits NLRP3 inflammasome activation by enhancing β-arrestin2-NLRP3 interaction, thus prevents neuronal degeneration. Futhermore, UNC9995 activates the Drd2/β-arrestin2 signaling to prevent inflammation-related genes transcription-induced by JAK/STAT3. UNC9995 improves depressive behavior in mouse model, and improves astrocytes dysfunctions. price>
R-R-4335 SKF 83822 CAS No.74115-08-5 SKF 83822/CAS No.74115-08-5 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not phospholipase C (PLC). SKF 83822 is also proved to stimulate AC via cAMP production. SKF 83822 can be used for research of schizophrenia. price>
R-R-4336 Rimcazole dihydrochloride CAS No.75859-03-9 Rimcazole (BW 234U) dihydrochloride/CAS No.75859-03-9 is a carbazole derivative that acts in part as a sigma (σ) receptor antagonist. Rimcazole dihydrochloride also binds with moderate affinity to the dopamine transporter and inhibit dopamine uptake. Rimcazole dihydrochloride can reduce locomotor activity and sensitization. Rimcazole dihydrochloride also can be used for the research of cancer. price>