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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4347 UCM-1306 CAS No.2258608-78-3 UCM-1306/CAS No.2258608-78-3 is a potent and orally active human dopamine D1 receptor allosteric modulator (PAM). UCM-1306 increases the endogenous dopamine (DA) maximal effect both in human and mouse D1 receptors. UCM-1306 is not only for improving motor symptoms but also for addressing the key comorbid cognitive impairment associated with long-term Parkinson disease (PD). price>
R-R-4348 L-745870 hydrochloride CAS No.1173023-36-3 L-745870 hydrochloride/CAS No.1173023-36-3 is a potent, selective, brain-penetrant and orally active dopamine D4 receptor antagonist with a Ki of 0.43 nM. L-745870 hydrochloride shows weaker affinity for D2 (Ki of 960 nM) and D3 (Ki of 2300 nM) receptors, and exhibits moderate affinity for 5-HT2 receptors, sigma sites and α-adrenoceptors. price>
R-R-4349 Trimethobenzamide hydrochloride CAS No.554-92-7 Trimethobenzamide hydrochloride/CAS No.554-92-7 is a blocker of the D2 receptor. Trimethobenzamide is an antiemetic used to prevent nausea and vomiting. price>
R-R-4350 ML417 CAS No.1386162-69-1 ML417/CAS No.1386162-69-1 is a selective and brain penetrant D3 dopamine receptor (D3R) agonist, with an EC50 of 38 nM. ML417 potently promotes D3R-mediated β-arrestin translocation, G protein mediated signaling, and pERK phosphorylation with minimal effects on other GPCR-mediated signaling. ML417 exhibits neuroprotection against toxin-induced neurodegeneration of dopaminergic neurons. price>
R-R-4351 SKF 77434 hydrobromide CAS No.300561-58-4 SKF 77434 hydrobromide/CAS No.300561-58-4 is a selective dopamine D1 receptor partial agonist. SKF 77434 hydrobromide has the potential to study cocaine addiction. price>
R-R-4352 L-Stepholidine CAS No.16562-13-3 L-Stepholidine (Stepholidine)/CAS No.16562-13-3 exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction. price>
R-R-4353 MLS1082 CAS No.883958-36-9 MLS1082/CAS No.883958-36-9 is a pyrimidone-based D1-like dopamine receptor positive allosteric modulator, with an EC50 of 123 nM for DA-stimulated G protein signaling. price>
R-R-4354 Molindone hydrochloride CAS No.15622-65-8 Molindone hydrochloride (EN-1733A)/CAS No.15622-65-8 is a therapeutic antipsychotic, used in the treatment of schizophrenia, works by blocking the effects of dopamine in the brain, leading to diminished psychoses. price>
R-R-4355 ABT-724 trihydrochloride CAS No.587870-77-7 ABT-724 trihydrochloride/CAS No.587870-77-7 is a potent and highly selective dopamine D4 receptor agonist with an EC50 of 12.4 nM for human dopamine D4 receptor. ABT-724 trihydrochloride is a potent partial agonist at the rat D4 (EC50 of 14.3 nM) and the ferret D4 receptor (EC50 of 23.2 nM), and has no effect on dopamine D1, D2, D3, or D5 receptors. ABT-724 trihydrochloride could be useful for the treatment of erectile dysfunction and has favorable side-effect profile. price>
R-R-4356 Bacopaside X CAS No.94443-88-6 Bacopaside X/CAS No.94443-88-6 is found in Bacopa monnieri, and shows a binding affinity toward the D1 receptor. price>