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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4268 CXCR2-IN-2 CAS No.1838123-21-9 CXCR2-IN-2/CAS No.1838123-21-9 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM. price>
R-R-4269 Ulocuplumab CAS No.1375830-34-4 Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338)/CAS No.1375830-34-4 is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models. price>
R-R-4270 SRT3190 CAS No.1204707-73-2 SRT3190/CAS No.1204707-73-2 is an antagonist of CXCR2, used in the research of chemokine mediated diseases. price>
R-R-4271 ALX 40-4C Trifluoroacetate ALX 40-4C Trifluoroacetate is a small peptide inhibitor of the chemokine receptor CXCR4, inhibits SDF-1 from binding CXCR4 with a Ki of 1 μM, and suppresses the replication of X4 strains of HIV-1; ALX 40-4C Trifluoroacetate also acts as an antagonist of the APJ receptor, with an IC50 of 2.9 μM. price>
R-R-4272 CTCE-9908 CAS No.1030384-98-5 CTCE-9908/CAS No.1030384-98-5 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells. price>
R-R-4273 ACT-777991 CAS No.1967811-46-6 ACT-777991/CAS No.1967811-46-6 is an orally active and selective CXCR3 antagonist. ACT-777991 has microsomes and hepatocytes stability across animal models. ACT-777991 inhibits the migration of activated T cells toward CXCL11. price>
R-R-4274 CXCR7 modulator 1 CAS No.2231812-31-8 CXCR7 modulator 1 (compound 25)/CAS No.2231812-31-8 is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM. price>
R-R-4275 (R,R)-CXCR2-IN-2 CAS No.1838123-22-0 (R,R)-CXCR2-IN-2/CAS No.1838123-22-0, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively. price>
R-R-4276 MSX-127 CAS No.6616-56-4 MSX-127/CAS No.6616-56-4 is a CXCR4 antagonist. MSX-127 inhibits cancer metastasis. price>
R-R-4277 MSX-130 CAS No.4051-59-6 MSX-130/CAS No.4051-59-6 is a CXCR4 antagonist. MSX-130 inhibits cancer metastasis. price>