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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4246 CXCR7 antagonist-1 CAS No.1613021-99-0 CXCR7 antagonist-1/CAS No.1613021-99-0 is a CXCR7 antagonist that inhibits the binding of the SDF-1 chemokine (also known as the CXCL12 chemokine) or I-TAC (also known as CXCL11) to the chemokine receptor CXCR7. CXCR7 antagonist-1 is useful in preventing tumor cell proliferation, tumor formation, inflammatory diseases, and many other diseases (extracted from patent WO2014085490A1, compound 1.128). price>
R-R-4247 ML 145 CAS No.1164500-72-4 ML 145/CAS No.1164500-72-4 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog. price>
R-C-2548 TG6-10-1 CAS:1415716-58-3 TG6-10-1 is an EP2 antagonist,shows low-nanomolar antagonist activity against only EP2,>300-fold selectivity over human EP3,EP4,and IP receptors,100-fold selectivity over EP1 receptors. price>
R-R-4248 NBI-74330 CAS No.855527-92-3 NBI-74330/CAS No.855527-92-3 is a potent antagonist for CXCR3, and exhibits potent inhibition of (125I)CXCL10 and (125I)CXCL11 specific binding with Ki of 1.5 and 3.2 nM, respectively. price>
R-R-4249 VUF11207 fumarate CAS No.1785665-61-3 VUF11207 fumarate/CAS No.1785665-61-3 is a CXCR7 agonist that binds specifically to CXCR7. VUF11207 fumarate reduces CXCL12-mediated osteoclastogenesis and bone resorption by inhibiting ERK phosphorylation. price>
R-R-4250 IT1t dihydrochloride CAS No.1092776-63-0 IT1t dihydrochloride/CAS No.1092776-63-0 is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. price>
R-R-4251 PS372424 hydrochloride CAS No.1596362-29-6 PS372424 hydrochloride/CAS No.1596362-29-6, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation. price>
R-R-4252 Reparixin L-lysine salt CAS No.266359-93-7 Reparixin L-lysine salt/CAS No.266359-93-7 is an allosteric inhibitor of chemokine receptor 1/2 (CXCR1/2) activation. price>
R-R-4253 TC14012 CAS No.368874-34-4 TC14012/CAS No.368874-34-4, a serum-stable derivative of T140, is a selective and peptidomimetic CXCR4 antagonist with an IC50 of 19.3 nM. TC14012 is a potent CXCR7 agonist with an EC50 of 350 nM for recruiting β-arrestin 2 to CXCR7. TC14012 has anti-HIV activity and anti-cancer activity. price>
R-R-4254 Kynurenic acid-d5 CAS No.350820-13-2 Kynurenic acid-d5/CAS No.350820-13-2 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8. price>