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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4238 Navarixin CAS No.473727-83-2 Navarixin (SCH 527123)/CAS No.473727-83-2 is a CXCR1 and CXCR2 antagonist that is potent, allosteric, and orally active, with Kd values of 41 nM for cynomolgus CXCR1 and 0.20 nM, 0.20 nM, 0.08 nM for mouse, rat and cynomolgus monkey CXCR2, respectively. price>
R-C-2539 Plerixafor（ AMD310） CAS：110078-46-1 Plerixafor(AMD 3100)is a selective CXCR4 antagonist with an IC50 of 44nM.Plerixafor,an immunostimulant and a hematopoietic stem cell(HSC)mobilizer, is an allosteric agonist of CXCR7.Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10nM. price>
R-R-4239 AZD-5069 CAS No.878385-84-3 AZD-5069/CAS No.878385-84-3 is a potent CXCR2 chemokine receptor antagonist, used for caner treatment. price>
R-C-2540 Ki16198 CAS：355025-13-7 Ki16198 is a potent and orally active LPA receptor antagonist,the methyl ester of Ki16425(HY-13285).Ki16198 inhibits LPA1 and LPA3-induced inositol phosphate production with Ki values of 0.34μM and 0.93μM,respectively.Ki16198 is effective for pancreatic cancer tumorigenesis and metastasis in vivo. price>
R-R-4240 Mavorixafor trihydrochloride CAS No.2309699-17-8 Mavorixafor trihydrochloride (AMD-070 trihydrochloride)/CAS No.2309699-17-8 is a potent, selective and orally available CXCR4 antagonist, with an IC50 value of 13 nM against CXCR4 125I-SDF binding, and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM, respectively. price>
R-R-4241 SCH 546738 CAS No.906805-42-3 SCH 546738/CAS No.906805-42-3 is a potent, orally active and non-competitive CXCR3 antagonist, the affinity constant (Ki) of SCH 546738 binding to human CXCR3 receptor is determined to be 0.4 nM in multiple experiments. price>
R-R-4242 SX-682 CAS No.1648843-04-2 SX-682/CAS No.1648843-04-2 is an orally bioavailable, potent allosteric inhibitor of CXCR1 and CXCR2. SX-682 can block tumor myeloid-derived suppressor cells (MDSCs) recruitment and enhance T cell activation and antitumor immunity. price>
R-R-4243 ACT-1004-1239 CAS No.2178049-58-4 ACT-1004-1239/CAS No.2178049-58-4 is a potent, selective, orally active CXCR7 antagonist with an IC50 value of 3.2 nM. price>
R-R-4244 NUCC-390 dihydrochloride CAS No.2749281-71-6 NUCC-390 dihydrochloride/CAS No.2749281-71-6 is a novel and selective small-molecule CXCR4 receptor agonist. NUCC-390 dihydrochloride induces internalization of CXCR4 receptors and acts in an opposite way of AMD3100 (HY-10046). NUCC-390 dihydrochloride promotes nerve recovery of function after neurodegeneration in vivo. price>
R-R-4245 SB-265610 CAS No.211096-49-0 SB-265610/CAS No.211096-49-0 is a selective, competitive, nonpeptide and allosteric CXCR2 antagonist. SB-265610 blocks rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization and neutrophil chemotaxis with IC50s of 3.7 nM and 70 nM, respectively. price>