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Home > products > apis> gpcr-g-protein
Catalog name Description price
R-R-4092 GW-405833 CAS No.180002-83-9 GW-405833 (L768242)/CAS No.180002-83-9 is a potent, selective cannabinoid receptor 2 (CB2) agonist with an EC50 of 50.7 nM. GW-405833 also behaves as a noncompetitive CB1 antagonist. GW-405833 suppresses inflammatory and neuropathic pain. price>
R-R-4093 Leelamine hydrochloride CAS No.16496-99-4 Leelamine hydrochloride/CAS No.16496-99-4 is a tricyclic diterpene molecule that is extracted from the bark of pine trees. Leelamine hydrochloride is a cannabinoid receptor type 1 (CB1) agonist and a inhibitor of SREBP1-regulated fatty acid/lipid synthesis in prostate cancer cells that is not affected by androgen receptor status. Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid synthesis[2,3]. price>
R-R-4094 MDA 19 CAS No.1048973-47-2 MDA 19/CAS No.1048973-47-2 is a potent and selective agonist of human cannabinoid receptor 2 (CB2), with a Ki of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity. price>
R-R-4095 Virodhamine CAS No.287937-12-6 Virodhamine/CAS No.287937-12-6 is an endocannabinoid, it regulates neurotransmission by activating the cannabinoid (CB) receptors. Virodhamine is an antagonist of CB1 receptor and an agonist of CB2 receptor. Virodhamine induces megakaryocytic differentiation by triggering MAPK signaling and ROS production. price>
R-R-4096 Etrinabdione CAS No.1818428-24-8 Etrinabdione (EHP-101; VCE-004.8)/CAS No.1818428-24-8 is an orally active, specific PPARγ and CB2 receptor dual agonist. Etrinabdione inhibits prolyl-hydroxylases (PHDs) and activates the HIF pathway. Etrinabdione, a semi-synthetic multitarget cannabinoquinoid, has potent anti-inflammatory activity. Etrinabdione attenuates adipogenesis and prevents diet-induced obesity. price>
R-R-4097 CB1 antagonist 2 CAS No.614726-85-1 CB1 antagonist 2/CAS No.614726-85-1 is caimabinoid 1 (CB1) antagonist extracted from patent WO2016184310A1, compound 3, inhibits CB1 in vivo with an IC50 of 25.5 nM. price>
R-C-2398 Prazosin HCl CAS:19237-84-4 Prazosin hydrochloride is a well-tolerated,CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders. Prazosin hydrochloride potently inhibits Norepinephrine(NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM.Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8, and 13μM,respectively. price>
R-R-4098 Tedalinab CAS No.916591-01-0 Tedalinab (GRC-10693)/CAS No.916591-01-0 is a potent, orally active, and selective cannabinoid receptor 2 (CB2) agonist. Tedalinab has >4700-fold functional selectivity for CB2 over CB1. Tedalinab has potential for neuropathic pain and osteoarthritis treatment. price>
R-R-4099 Pregnenolone-d4-1 CAS No.61574-54-7 Pregnenolone-d4-1/CAS No.61574-54-7 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels. price>
R-R-4100 GAT211 CAS No.102704-40-5 GAT211/CAS No.102704-40-5 is a cannabinoid 1 receptor (CB1R) positive allosteric modulator (PAM). GAT211 activates cAMP and β-arrestin2 with EC50 values of 260 nM and 650 nM, respectively. GAT211 inhibits GAT211 can be used for neuropathic and/or inflammatory pain research. price>