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Catalog name Description price
R-R-3986 OPC-28326 CAS No.167626-17-7 OPC-28326/CAS No.167626-17-7 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55 nM for α2A-, α2B- and α2C-adrenoceptors, respectively. price>
R-R-3987 Esmolol-d7 hydrochloride CAS No.1346598-13-7 Esmolol-d7 (hydrochloride)/CAS No.1346598-13-7 is the deuterium labeled Esmolol hydrochloride. Esmolol hydrochloride is a beta adrenergic receptor blocker. price>
R-R-3988 Dronedarone-d6 hydrochloride CAS No.1329809-23-5 Dronedarone-d6 (hydrochloride)/CAS No.1329809-23-5 is the deuterium labeled Dronedarone. Dronedarone hydrochloride, a derivative of Amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone hydrochloride is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone hydrochloride is a substrate for and a moderate inhibitor of CYP3A4. price>
R-R-3989 Midaglizole hydrochloride CAS No.79689-25-1 Midaglizole hydrochloride (DG5128)/CAS No.79689-25-1 is a preferential α2-adrenoceptor antagonist. Midaglizole hydrochloride (DG5128) exhibits 7.4 times higher affinity (pKi=6.28) toward α2-adrenoceptor than α1-adrenoceptor. price>
R-R-3990 Tranilast CAS No.53902-12-8 Tranilast (MK-341)/CAS No.53902-12-8 acts as an anti-atopic agent. Tranilast suppresses production of prostaglandin D2 (PGD2, IC50= 0.1 mM). Tranilast sodium exhibits anti-inflammatory and immunomodulatory effects. Tranilast sodium antagonizes angiotensin II and inhibits its biological effects in vascular smooth muscle cells. price>
R-R-3991 Valsartan CAS No.137862-53-4 Valsartan (CGP 48933)/CAS No.137862-53-4 is an angiotensin II receptor antagonist and has the potential for high blood pressure and heart failure research. price>
R-R-3992 Talfirastide CAS No.51833-78-4 Angiotensin 1-7 (Ang-(1-7))/CAS No.51833-78-4 is an endogenous heptapeptide from the renin-angiotensin system (RAS) with a cardioprotective role due to its anti-inflammatory and anti-fibrotic activities in cardiac cells. Angiotensin 1-7 inhibits purified canine ACE activity (IC50=0.65 μM). Angiotensin 1-7 acts as a local synergistic modulator of kinin-induced vasodilation by inhibiting ACE and releasing nitric oxide. Angiotensin 1-7 blocks Ang II-induced smooth muscle cell proliferation and hypertrophy and shows antiangiogenic and growth-inhibitory effects on the endothelium. Angiotensin 1-7 shows anti-inflammatory activity . price>
R-R-3993 Buloxibutid CAS No.477775-14-7 Buloxibutid (AT2 receptor agonist C21)/CAS No.477775-14-7 is a agentlike selective angiotensin II AT2 receptor agonist with Ki values of 0.4 nM and >10 μM for the AT2 receptor and AT1 receptor, respectively. price>
R-R-3994 Irbesartan CAS No.138402-11-6 Irbesartan (SR-47436)/CAS No.138402-11-6 is an orally active Ang II type 1 (AT1) receptor blocker (ARB). Irbesartan can relax the blood vessels, low blood pressure and increase the supply of blood and oxygen to the heart. Irbesartan can be used for the research of high blood pressure, heart failure, and diabetic kidney disease. price>
R-R-3995 Olmesartan CAS No.144689-24-7 Olmesartan (RNH-6270)/CAS No.144689-24-7 is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure. price>