Product apis-dna-damage-dna-repa

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Catalog	name	Description	price
R-R-4530	SG2057 CAS No.260417-62-7	SG2057 (DRG16)/CAS No.260417-62-7 is a PBD dimer containing a pentyldioxy linkage which binds sequence selectively in the minor groove of DNA forming DNA interstrand and intrastrand cross-linked adducts. SG2057 is a highly active antitumor agent.	price>
R-R-4531	Nimustine hydrochloride CAS No.55661-38-6	Nimustine hydrochloride (ACNU)/CAS No.55661-38-6 is a DNA cross-linking and DNA alkylating agent, which induces DNA replication blocking lesions and DNA double-strand breaks and inhibits DNA synthesis, commonly used in chemotherapy for glioblastomas.	price>
R-R-4532	PK11000 CAS No.38275-34-2	PK11000/CAS No.38275-34-2 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding. PK11000 has anti-tumor activities.	price>
R-R-4533	Imifoplatin CAS No.1339960-28-9	Imifoplatin (PT-112)/CAS No.1339960-28-9 is a platinum-based agent belonging to the phosphaplatin family. Imifoplatin exhibits antineoplastic activity.	price>
R-R-4534	Duocarmycin SA CAS No.130288-24-3	Duocarmycin SA/CAS No.130288-24-3 is an orally active antitumor antibiotic with an IC50 of 10 pM. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro.	price>
R-R-4535	Semustine CAS No.13909-09-6	Semustine/CAS No.13909-09-6 is a DNA alkylator, binds to DNA, and acts as a cancer chemotherapeutic agent.	price>
R-R-4536	Pipobroman CAS No.54-91-1	Pipobroman/CAS No.54-91-1 is a bromide derivative of piperazine and acts as an alkylating agent. Pipobroman plays its role by inhibiting DNA and RNA polymerase or by reducing pyrimidine nucleotide incorporation into DNA. Pipobroman can be used for the cancer research, including polycythemia vera, myeloproliferative neoplasm, and AML et.al.	price>
R-R-4537	Phenanthriplatin CAS No.1416900-51-0	Phenanthriplatin/CAS No.1416900-51-0 is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells.	price>
R-R-4538	Bizelesin CAS No.129655-21-6	Bizelesin (NSC 615291; U-77779)/CAS No.129655-21-6 is an AT-specific DNA alkylating agent that can generate DNA interstrand crosslinks, effectively inhibit DNA replication, and has potential anticancer activity.	price>
R-R-4539	PR-104 CAS No.851627-62-8	PR-104/CAS No.851627-62-8 is a selective hypoxia-activated DNA cross-linking agent and can be used for the research of multiple tumor xenograft models. PR-104, as a nitrogen mustard pre-proagent, is converted efficiently to the more lipophilic dinitrobenzamide mustards alcohol PR-104A.	price>

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